Evidence map›Paper›PMID 38664011›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

Calcium-Dependent Regulation of Neuronal Excitability Is Rescued in Fragile X Syndrome by a Tat-Conjugated N-Terminal Fragment of FMRP.

Xiaoqin Zhan, Hadhimulya Asmara, Paul Pfaffinger, Ray W Turner

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Xiaoqin ZhanHotchkiss Brain Institute, Baylor College of Medicine, Houston, Texas 77030.
Hadhimulya AsmaraHotchkiss Brain Institute, Baylor College of Medicine, Houston, Texas 77030.ORCID 0000-0002-5543-5576
Paul PfaffingerDepartment of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
Ray W TurnerHotchkiss Brain Institute, Baylor College of Medicine, Houston, Texas 77030 rwturner@ucalgary.ca.
Baylor College of Medicine · USUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fragile X syndrome (FXS) arises from the loss of fragile X messenger ribonucleoprotein (FMRP) needed for normal neuronal excitability and circuit functions. Recent work revealed that FMRP contributes to mossy fiber long-term potentiation by adjusting the Kv4 A-type current availability through interactions with a Cav3-Kv4 ion channel complex, yet the mechanism has not yet been defined. In this study using wild-type and

Indexed as

CalciumFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeMice, KnockoutNeuronsAnimalsMaleMiceMice, Inbred C57BLShal Potassium Channelstat Gene Products, Human Immunodeficiency VirusCalciumFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1Shal Potassium Channelstat Gene Products, Human Immunodeficiency VirusCav3-Kv4cerebellumDUSPERKfragile X syndromegranule cell

Identifiers

PMID38664011
PMCPMC11112635
OpenAlexW4395478551

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.