Evidence map›Paper›PMID 38663907›Full record

ArticleAging2024

The association between neighborhood deprivation and DNA methylation in an autopsy cohort.

Lindsay Pett, Zhenjiang Li, Sarina Abrishamcar, Kenyaita Hodge, Todd Everson, Grace Christensen, Marla Gearing, Michael S Kobor, Chaini Konwar, Julia L MacIsaac and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Metabolic dysregulation in Alzheimer's disease: A brain metabolomics approach.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Lindsay PettDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Zhenjiang LiGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Sarina AbrishamcarDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Kenyaita HodgeGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Todd EversonDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Grace ChristensenDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Marla GearingDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA.
Michael S KoborDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Chaini KonwarDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Julia L MacIsaacDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Kristy DeverDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Aliza P WingoDivision of Mental Health, Atlanta VA Medical Center, Decatur, GA 30033, USA.
Allan LeveyDepartment of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.
James J LahDepartment of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Thomas S WingoDepartment of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Anke HülsDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Emory University · USUniversity of British Columbia · CAAtlanta VA Medical Center · USBC Children's Hospital · CAPacific Centre for Reproductive Medicine · CA

Funding

The Emory Alzheimer's Disease CenterP50AG025688 · NIA · EMORY UNIVERSITY · PI WINGO, THOMAS SPURGEON · 2005 to 2019
$25.7M
UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6M
Graduate and Postdoctoral Training in ToxicologyT32ES012870 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2004 to 2026
$9.1M
Air pollution and early signs of dementiaR01AG079170 · NIA · EMORY UNIVERSITY · PI Anke Huels, Thomas Spurgeon Wingo · 2022 to 2026
$3.6M
NIA NIH HHS P30 AG072972NIA NIH HHS P50 AG025688NIA NIH HHS R01 AG079170NIEHS NIH HHS P30 ES019776NIEHS NIH HHS T32 ES012870
6 · The paper itself

Abstract

Previous research has found that living in a disadvantaged neighborhood is associated with poor health outcomes. Living in disadvantaged neighborhoods may alter inflammation and immune response in the body, which could be reflected in epigenetic mechanisms such as DNA methylation (DNAm). We used robust linear regression models to conduct an epigenome-wide association study examining the association between neighborhood deprivation (Area Deprivation Index; ADI), and DNAm in brain tissue from 159 donors enrolled in the Emory Goizueta Alzheimer's Disease Research Center (Georgia, USA). We found one CpG site (cg26514961, gene

Indexed as

AutopsyCpG IslandsDNA MethylationAgedAged, 80 and overAlzheimer DiseaseBrainCohort StudiesEpigenesis, GeneticFemaleGenome-Wide Association StudyHumansMaleNeighborhood Characteristicsbrain tissueDNA methylationepigeneticsneighborhood deprivationneuropathology

Identifiers

PMID38663907
PMCPMC11087100
OpenAlexW4395082663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.