Evidence map›Paper›PMID 38663667›Full record

ArticleEnvironmental research2024

Gestational PBDE concentrations, persistent externalizing, and emerging internalizing behaviors in adolescents: The HOME study.

Kim M Cecil, Yingying Xu, Aimin Chen, Jane Khoury, Mekibib Altaye, Joseph M Braun, Andreas Sjodin, Bruce P Lanphear, Nicholas Newman, Jeffrey R Strawn and 2 more

Open access · greenAbstract read
In one paragraph

Article in Environmental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
7.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Gestational PBDE concentrations and functional connectivity in adolescents: The HOME Study.International journal of hygiene and environmental health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Kim M CecilDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: kim.cecil@cchmc.org.
Yingying XuDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Aimin ChenDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Jane KhouryDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Mekibib AltayeDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Joseph M BraunDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Andreas SjodinDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Bruce P LanphearDepartment of Health Sciences, Simon Fraser University, Burnaby BC, Canada.
Nicholas NewmanDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Jeffrey R StrawnDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Ann M VuongDepartment of Epidemiology and Biostatistics, School of Public Health, University of Nevada, Las Vegas, NV, USA.
Kimberly YoltonDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Cincinnati Children's Hospital Medical Center · USBrown University · USCenters for Disease Control and Prevention · USSimon Fraser University · CAUniversity of Cincinnati Medical Center · USUniversity of Nevada, Las Vegas · USUniversity of Pennsylvania · US

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI YADAV, JAGJIT S · 1992 to 2022
$35.4M
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Rebecca A Simmons · 2006 to 2026
$35.3M
Study of Prevalent Neurotoxicants in ChildrenP01ES011261 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI LANPHEAR, BRUCE P · 2001 to 2006
$6.4M
Longitudinal Impact of Air Pollution on Mental Health and Neuroimaging Outcomes during Adolescence in the Cincinnati Combined Childhood Cohorts (C4)R01ES031621 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI CECIL, KIM M, RYAN, PATRICK H · 2021 to 2025
$5.3M
Impact of pre- and postnatal chemical mixture exposures on child neurobehavior and neuroimagingR01ES033054 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI CHEN, AIMIN · 2021 to 2025
$3.3M
Early life perfluoroalkyl substance exposure & obesity: Mechanisms & phenotypingR01ES025214 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2016 to 2020
$3.1M
Internalizing Behaviors and Neuroimaging Outcomes: Impact of PBDE and PFC ExposuresR01ES027224 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI CECIL, KIM M, YOLTON, KIMBERLY · 2016 to 2020
$3.0M
Longitudinal study of exposure to PBDEs and PFCs and child neurobehaviorR01ES020349 · NIEHS · UNIVERSITY OF CINCINNATI · PI CHEN, AIMIN, LANPHEAR, BRUCE P · 2011 to 2015
$2.9M
Improving the Effectiveness and Safety of Escitalopram in Pediatric Anxiety Disorders Using Pharmacogenetically-guided DosingR01HD099775 · NICHD · UNIVERSITY OF CINCINNATI · PI RAMSEY, LAURA B, STRAWN, JEFFREY ROBERT · 2020 to 2024
$2.9M
Estracellular Vesicles as Non-Invasive Predictors of Antidepressant Outcomes in Pediatric AnxietyR01HD098757 · NICHD · UNIVERSITY OF CINCINNATI · PI STRAWN, JEFFREY ROBERT · 2019 to 2024
$2.4M
Gestational PFAS Mixture Exposures, Longitudinal Metabolomic Profiles, and Adolescent Cardiometabolic HealthR01ES032836 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2021 to 2024
$2.4M
Early life organophosphate ester (OPE) exposures and adiposity and cardiometabolic health during adolescenceR01ES033200 · NIEHS · UNIVERSITY OF NEVADA LAS VEGAS · PI Ann Vuong · 2022 to 2026
$2.0M
NICHD NIH HHS R01 HD098757NICHD NIH HHS R01 HD099775NIEHS NIH HHS P01 ES011261NIEHS NIH HHS P30 ES006096NIEHS NIH HHS P30 ES013508NIEHS NIH HHS R01 ES020349NIEHS NIH HHS R01 ES025214NIEHS NIH HHS R01 ES027224NIEHS NIH HHS R01 ES031621NIEHS NIH HHS R01 ES032836NIEHS NIH HHS R01 ES033054NIEHS NIH HHS R01 ES033200
6 · The paper itself

Abstract

backgroundPolybrominated diphenyl ethers (PBDEs) are ubiquitous environmental chemicals used as flame retardants in commercial and consumer products. Gestational PBDE concentrations are associated with adverse behaviors in children; however, the persistence of these associations into adolescence remains understudied.

objectiveWe estimated the association of gestational PBDE serum concentrations with early adolescent self- and caregiver-reported behaviors at age 12 years and determined the consistency with previously observed associations in childhood with caregiver-reported behaviors in a prospective pregnancy and birth cohort.

methodsWe measured maternal serum concentrations of five individual PBDE congeners and created a summary exposure variable (∑

resultsGestational PBDE concentrations were positively associated with adolescent-reported BASC3 composite indices for inattention & hyperactivity (BDE-28, -47, -99, -100, ∑ DISCUSSION: Gestational PBDE serum concentrations were associated with self-reported internalizing and externalizing behavior problems in early adolescence. Caregiver-reported externalizing behaviors recognized during childhood remain associated with gestational PBDE concentrations and persist into early adolescence. Internalizing behaviors were less recognized by caregivers.

Indexed as

Environmental PollutantsHalogenated Diphenyl EthersPrenatal Exposure Delayed EffectsAdolescentAdolescent BehaviorChildFemaleFlame RetardantsHumansMaleMaternal ExposurePregnancyProspective StudiesEnvironmental PollutantsFlame RetardantsHalogenated Diphenyl EthersAdolescentAttentionExternalizing behaviorsGestationalInternalizing behaviorsPolybrominated diphenyl ether flame retardants

Identifiers

PMID38663667
PMCPMC11152989
OpenAlexW4395032836

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.