Evidence map›Paper›PMID 38663092›Full record

ReviewAnnual review of neuroscience2024

Cerebellar Functions Beyond Movement and Learning.

Linda H Kim, Detlef H Heck, Roy V Sillitoe

Abstract readReview
In one paragraph

Review in Annual review of neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  14. Brain-wide mapping of developmental trajectories of cerebellar efferent projections.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  16. Essential new insights into human cerebellar Purkinje cell biology from studies of essential tremor.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Linda H KimJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, Texas, USA.
Detlef H HeckCenter for Cerebellar Network Structure and Function in Health and Disease, University of Minnesota, Duluth, Minnesota, USA.
Roy V SillitoeDepartments of Neuroscience and Pediatrics, Program in Developmental Biology, and Development, Disease Models & Therapeutics Graduate Program, Baylor College of Medicine, Houston, Texas, USA.

Funding

Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MIRJANA MALETIC-SAVATIC · 2020 to 2026
$9.9M
Neuronal mechanisms of cerebellar cognitive functionR01MH112143 · NIMH · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI HECK, DETLEF H · 2018 to 2022
$2.3M
Cerebellar Deep Brain StimulationR01NS119301 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2020 to 2024
$2.0M
Spatial and temporal pathophysiology of developmental dystoniaR01NS127435 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Roy Vincent Sillitoe · 2022 to 2026
$2.0M
CEREBELLAR FUNCTION IN TREMORR01NS100874 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2017 to 2021
$1.9M
NICHD NIH HHS P50 HD103555NIMH NIH HHS R01 MH112143NINDS NIH HHS R01 NS100874NINDS NIH HHS R01 NS119301NINDS NIH HHS R01 NS127435
6 · The paper itself

Abstract

The cerebellum has a well-established role in controlling motor functions, including coordination, posture, and the learning of skilled movements. The mechanisms for how it carries out motor behavior remain under intense investigation. Interestingly though, in recent years the mechanisms of cerebellar function have faced additional scrutiny since nonmotor behaviors may also be controlled by the cerebellum. With such complexity arising, there is now a pressing need to better understand how cerebellar structure, function, and behavior intersect to influence behaviors that are dynamically called upon as an animal experiences its environment. Here, we discuss recent experimental work that frames possible neural mechanisms for how the cerebellum shapes disparate behaviors and why its dysfunction is catastrophic in hereditary and acquired conditions-both motor and nonmotor. For these reasons, the cerebellum might be the ideal therapeutic target.

Indexed as

CerebellumLearningMovementAnimalsHumanscerebellumcognitionlearningmovementrewardsleep

Identifiers

PMID38663092
PMCPMC13371864

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.