Evidence map›Paper›PMID 38662992›Full record

ArticleBiomacromolecules2024

Targeted pH-Activated Peptide-Based Nanomaterials for Combined Photodynamic Therapy with Immunotherapy.

Bingbing Sun, Haowen Yang, Yudong Li, Jari F Scheerstra, Marleen H M E van Stevendaal, Shukun Li, Jan C M van Hest

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Nanocarriers for cutting-edge cancer immunotherapies.Journal of translational medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bingbing SunBio-Organic Chemistry, Department of Chemical Engineering and Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology Helix, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
Haowen YangLaboratory of Immunoengineering, Department of Biomedical Engineering, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.ORCID 0000-0002-3196-8917
Yudong LiBio-Organic Chemistry, Department of Chemical Engineering and Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology Helix, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
Jari F ScheerstraBio-Organic Chemistry, Department of Chemical Engineering and Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology Helix, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
Marleen H M E van StevendaalBio-Organic Chemistry, Department of Chemical Engineering and Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology Helix, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
Shukun LiBio-Organic Chemistry, Department of Chemical Engineering and Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology Helix, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
Jan C M van HestBio-Organic Chemistry, Department of Chemical Engineering and Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology Helix, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.ORCID 0000-0001-7973-2404
Eindhoven University of Technology · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy (PDT) has demonstrated efficacy in eliminating local tumors, yet its effectiveness against metastasis is constrained. While immunotherapy has exhibited promise in a clinical context, its capacity to elicit significant systemic antitumor responses across diverse cancers is often limited by the insufficient activation of the host immune system. Consequently, the combination of PDT and immunotherapy has garnered considerable attention. In this study, we developed pH-responsive porphyrin-peptide nanosheets with tumor-targeting capabilities (PRGD) that were loaded with the IDO inhibitor NLG919 for a dual application involving PDT and immunotherapy (PRGD/NLG919). In vitro experiments revealed the heightened cellular uptake of PRGD/NLG919 nanosheets in tumor cells overexpressing αvβ3 integrins. The pH-responsive PRGD/NLG919 nanosheets demonstrated remarkable singlet oxygen generation and photocytotoxicity in HeLa cells in an acidic tumor microenvironment. When treating HeLa cells with PRGD/NLG919 nanosheets followed by laser irradiation, a more robust adaptive immune response occurred, leading to a substantial proliferation of CD3

Indexed as

ImmunotherapyNanostructuresPhotochemotherapyAnimalsHeLa CellsHumansHydrogen-Ion ConcentrationImidazolesIsoindolesMiceNeoplasmsPeptidesPhotosensitizing AgentsPorphyrinsTumor Microenvironment1-cyclohexyl-2-(5H-imidazo(5,1-a)isoindol-5-yl)ethanolImidazolesIsoindolesPeptidesPhotosensitizing AgentsPorphyrins

Identifiers

PMID38662992
PMCPMC11094723
OpenAlexW4395446128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.