Evidence map›Paper›PMID 38662860›Full record

ReviewCirculation research2024

Understanding the Cardiovascular and Metabolic Health Effects of Air Pollution in the Context of Cumulative Exposomic Impacts.

Haitham Khraishah, Zhuo Chen, Sanjay Rajagopalan

Abstract readReview
In one paragraph

Review in Circulation research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
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  11. Journal of the American Heart Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Haitham KhraishahDivision of Cardiovascular Medicine, University of Maryland Medical Center, Baltimore (H.K.).ORCID 0000-0003-0003-5089
Zhuo ChenHarrington Heart and Vascular Institute, University Hospitals, Cleveland, OH (Z.C., S.R.).
Sanjay RajagopalanHarrington Heart and Vascular Institute, University Hospitals, Cleveland, OH (Z.C., S.R.).ORCID 0000-0001-6669-8163

Funding

ACHIEVE P3 - CHDP50MD017351 · NIMHD · WAYNE STATE UNIVERSITY · PI LEVY, PHILLIP DAVID · 2021 to 2025
$21.1M
Diversity Suppplement (CIRCADIAN) Circadian Disruption as Mediator of Cardiometabolic Risk in Air PollutionR35ES031702 · NIEHS · CASE WESTERN RESERVE UNIVERSITY · PI Sanjay Rajagopalan · 2021 to 2026
$5.9M
Targets and targeting of immunometabolism in chronic PM2.5 exposureR01ES033670 · NIEHS · CASE WESTERN RESERVE UNIVERSITY · PI Andrei Maiseyeu, Sanjay Rajagopalan · 2022 to 2026
$2.2M
Diet-Environment Interactions in InflammationR01ES017290 · NIEHS · UNIVERSITY OF MARYLAND BALTIMORE · PI RAJAGOPALAN, SANJAY · 2010 to 2014
$1.8M
NIEHS NIH HHS R01 ES017290NIEHS NIH HHS R01 ES033670NIEHS NIH HHS R35 ES031702NIMHD NIH HHS P50 MD017351
6 · The paper itself

Abstract

Poor air quality accounts for more than 9 million deaths a year globally according to recent estimates. A large portion of these deaths are attributable to cardiovascular causes, with evidence indicating that air pollution may also play an important role in the genesis of key cardiometabolic risk factors. Air pollution is not experienced in isolation but is part of a complex system, influenced by a host of other external environmental exposures, and interacting with intrinsic biologic factors and susceptibility to ultimately determine cardiovascular and metabolic outcomes. Given that the same fossil fuel emission sources that cause climate change also result in air pollution, there is a need for robust approaches that can not only limit climate change but also eliminate air pollution health effects, with an emphasis of protecting the most susceptible but also targeting interventions at the most vulnerable populations. In this review, we summarize the current state of epidemiologic and mechanistic evidence underpinning the association of air pollution with cardiometabolic disease and how complex interactions with other exposures and individual characteristics may modify these associations. We identify gaps in the current literature and suggest emerging approaches for policy makers to holistically approach cardiometabolic health risk and impact assessment.

Indexed as

Air PollutionCardiovascular DiseasesEnvironmental ExposureAir PollutantsCardiometabolic Risk FactorsExposomeHumansMetabolic DiseasesParticulate MatterAir PollutantsParticulate Matterair pollutioncardiometaboliccardiovascular diseasesdisparitiesexposomeparticulate matter

Identifiers

PMID38662860
PMCPMC11253082

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.