ArticleScience (New York, N.Y.)2024
Vitamin D regulates microbiome-dependent cancer immunity.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07007169 (Mediterranean Diet and Inequality in Early Breast Cancer), which is not on this map. Cited by 83 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
48.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mediterranean Diet and Inequality in Early Breast Cancer: A Multicenter Randomized Clinical Trial
Who cites it
83 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.
- PD-1/PD-L1 immune checkpoint blockade in breast cancer: research insights and sensitization strategies.Molecular cancer · 2024Pooled it
- Gemcitabine and nab-paclitaxel with or without the VDR agonist paricalcitol for metastatic pancreatic cancer: a randomized, multiarm, run-in phase trial.Nature cancer · 2026Trial
- Metabolic immune checkpoints (MICs) in cancer: from molecular mechanisms to challenges and opportunities in clinical translation.Signal transduction and targeted therapy · 2026Review
- The vitamin D receptor story: discovery, control, and genomic reach.The Journal of endocrinology · 2026Review
- The Impact of Oral-Gut Microbiota Structure and Its Manipulation on RA Development and Management.Food science & nutrition · 2026Review
- VDR Activation Suppresses Pancreatic Cancer Metastasis Through Inhibition of the ERK Signaling Pathway.Cancers · 2026Article
- The lethal symbiont: exploring the pathophysiology of cancer.Physiological reviews · 2026Review
- A Microbial Lipid-ATP Synthase Axis Fuels NK Cell Antitumor Activity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dietary yacon concentrate reshapes microbial-metabolite crosstalk to inhibit colorectal cancer.NPJ science of food · 2026Article
- Disruption of the spinal cord-gut axis alters microbial dynamics and carbohydrate cross-feeding in the gut.Communications biology · 2026Article
- Impact of vitamin D plasma levels on in vitro natural killer cell cytotoxicity against non-small cell lung carcinoma in the presence of nivolumab.Internal and emergency medicine · 2026Article
- Harnessing the microbiome for cancer therapy.Nature reviews. Microbiology · 2026Review
- The mycobiome, virome and archaeome in gastrointestinal cancers: molecular pathogenesis and therapeutic intervention.Molecular cancer · 2026Review
- Vitamin D receptor isoform VDRA suppresses hepatocellular tumorigenesis by restricting YAP nuclear localization.Cell death & disease · 2026Article
- Review
- Tumor-resident bacteria in gastrointestinal cancers: from regulatory mechanisms to clinical implications.Cancer biology & medicine · 2026Review
- Article
- Vitamin D and Health Outcomes: State-of-the-Art Review of Triangulated Evidence and Ongoing Controversies.Current nutrition reports · 2026Review
- Vitamin D and hypoxia-inducible factors signaling interplay: A hypothesis-driven review of therapeutic strategies for acute cerebral infarction.Metabolic brain disease · 2026Review
- Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
39 authors at 8 institutions in 3 countries.
Evangelos GiampazoliasImmunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Mariana Pereira da Costa *Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0002-9715-5601
Khiem C Lam *Inflammatory Cell Dynamics Section, Laboratory of Integrative Cancer Immunology (LICI), Center for Cancer Research (CCR), National Cancer Institute (NCI), Bethesda, MD 20892, USA.ORCID 0000-0001-5831-1264
Kok Haw Jonathan Lim *Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0002-6544-9218
Ana Cardoso *Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0002-4610-4337
Cécile Piot *Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0001-7639-3662
Probir ChakravartyBioinformatics and Biostatistics STP, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0003-1146-8824
Sonja BlascheMRC Toxicology Unit, University of Cambridge, Cambridge CB2 1QR, UK.ORCID 0000-0001-9422-0474
Swara PatelCancer Immunosurveillance Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.ORCID 0009-0002-7133-6110
Adi BiramImmunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0001-6169-9861
Tomas Castro-DopicoImmunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0002-6964-5478
Michael D BuckImmunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0002-9611-1199
Richard R RodriguesBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.ORCID 0000-0003-3985-3003
Gry Juul PoulsenNational Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease, PREDICT, Faculty of Medicine, Aalborg University, Department of Gastroenterology and Hepatology, Aalborg University Hospital, A DK-2450 Copenhagen, Denmark.ORCID 0000-0003-2744-2469
Susana A Palma-DuranMetabolomics STP, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0002-4210-3855
Neil C RogersImmunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0001-8977-7585
Maria A KoufakiCancer Inflammation and Immunity Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.ORCID 0000-0002-5058-0176
Carlos M MinuttiImmunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0002-9663-1928
Pengbo WangCancer Immunosurveillance Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.
Alexander VdovinCancer Immunosurveillance Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.ORCID 0000-0003-0810-4659
Bruno FredericoImmunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0002-6985-3090
Eleanor ChildsImmunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0002-1167-8672
Sonia LeeImmunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0009-0008-6999-2905
Ben SimpsonTumor Immunogenomics and Immunosurveillance (TIGI) Lab, UCL Cancer Institute, London WC1E 6DD, UK.
Andrea IsepponAhRimmunity Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0009-0002-5796-6845
Sara OmenettiAhRimmunity Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0002-2443-3631
Gavin KellyBioinformatics and Biostatistics STP, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0001-7219-560X
Robert GoldstoneBioinformatics and Biostatistics STP, The Francis Crick Institute, London NW1 1AT, UK.
Emma NyeExperimental Histopathology, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0001-9154-3526
Alejandro Suárez-BonnetExperimental Histopathology, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0003-0296-5896
Simon L PriestnallExperimental Histopathology, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0002-6027-1879
James I MacRaeMetabolomics STP, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0002-1464-8583
Santiago ZelenayCancer Inflammation and Immunity Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.ORCID 0000-0002-6865-3978
Kiran Raosaheb PatilMRC Toxicology Unit, University of Cambridge, Cambridge CB2 1QR, UK.ORCID 0000-0002-6166-8640
Kevin LitchfieldTumor Immunogenomics and Immunosurveillance (TIGI) Lab, UCL Cancer Institute, London WC1E 6DD, UK.
James C LeeGenetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0001-5711-9385
Tine JessNational Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease, PREDICT, Faculty of Medicine, Aalborg University, Department of Gastroenterology and Hepatology, Aalborg University Hospital, A DK-2450 Copenhagen, Denmark.
Romina S GoldszmidInflammatory Cell Dynamics Section, Laboratory of Integrative Cancer Immunology (LICI), Center for Cancer Research (CCR), National Cancer Institute (NCI), Bethesda, MD 20892, USA.ORCID 0000-0001-8801-8528
Caetano Reis e SousaImmunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0001-7392-2119
The Francis Crick Institute · GBCancer Research UK Manchester Institute · GBAalborg University Hospital · DKCancer Research UK · GBCenter for Cancer Research · USRoyal Veterinary College · GBUniversity of Cambridge · GBFrederick National Laboratory for Cancer Research · US
Funding
LICI Microbiome and Genetics CoreZICBC011237 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI OHUIGIN, COLM · 2009 to 2025
$28.3MRole of the microbiota in regulating the mononuclear phagocyte systemZIABC011670 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GOLDSZMID, ROMINA · 2015 to 2025
$11.7MEuropean Research Council 268670European Research Council 866028Medical Research Council CC2090Medical Research Council MC_UU_00025/11Wellcome Trust 106973Wellcome Trust 216327Wellcome Trust CC2090
Abstract
A role for vitamin D in immune modulation and in cancer has been suggested. In this work, we report that mice with increased availability of vitamin D display greater immune-dependent resistance to transplantable cancers and augmented responses to checkpoint blockade immunotherapies. Similarly, in humans, vitamin D-induced genes correlate with improved responses to immune checkpoint inhibitor treatment as well as with immunity to cancer and increased overall survival. In mice, resistance is attributable to the activity of vitamin D on intestinal epithelial cells, which alters microbiome composition in favor of
Indexed as
Bacteroides fragilisGastrointestinal MicrobiomeImmune Checkpoint InhibitorsNeoplasmsVitamin DAnimalsCalcifediolCell Line, TumorDietFemaleHumansImmunotherapyIntestinal MucosaMaleMiceMice, Inbred C57BLCalcifediolImmune Checkpoint InhibitorsVitamin DVitamin D-Binding Protein
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
NCT07007169ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.