Evidence map›Paper›PMID 38662634›Full record

SynthesisPloS one2024

Level of adherence to option B+ program and associated factors among HIV-positive women in Ethiopia: A systematic review and meta-analysis.

Alemu Degu Ayele, Bekalu Getnet Kassa, Gedefaye Nibret Mihretie, Habtamu Gebrehana Belay, Dagne Addisu Sewyew, Abenezer Melkie Semahegn, Enyew Dagnew Yehuala, Gebrehiwot Ayalew Tiruneh, Lebeza Alemu Tenaw, Abrham Debeb Sendekie and 5 more

Open access · goldAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Alemu Degu AyeleDepartment of Midwifery, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.ORCID 0000-0002-2777-4108
Bekalu Getnet KassaDepartment of Midwifery, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Gedefaye Nibret MihretieDepartment of Midwifery, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Habtamu Gebrehana BelayDepartment of Midwifery, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Dagne Addisu SewyewDepartment of Midwifery, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Abenezer Melkie SemahegnDepartment of Midwifery, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Enyew Dagnew YehualaDepartment of Midwifery, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Gebrehiwot Ayalew TirunehDepartment of Midwifery, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Lebeza Alemu TenawSchool of Public Health, College of Health Sciences, Woldia University, Woldia, Ethiopia.
Abrham Debeb SendekieCollege of Medicine and Health Sciences, Wachemo University, Hossana, Ethiopia.
Adanech Getie TefferaDepartment of Midwifery, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Eden Workneh AychewDepartment of Midwifery, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Yismaw Yimam BelachewSchool of Medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Tewachew Muche LiyehDepartment of Midwifery, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Mulugeta Dile WorkeDepartment of Midwifery, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.ORCID 0000-0003-2540-9809
Debre Tabor University · ETWachemo UniversityWoldia University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite policy initiatives and strategic measures highly focused on preventing mother-to-child transmission through the implementation of the Option B+ program, adherence to the treatment is still challenging. The level of adherence and determinants of Option B+ program utilization reported by different studies were highly inconsistent in Ethiopia. Hence, this systematic review and meta-analysis aimed to estimate the pooled prevalence of adherence to the Option B+ program and its predictors among HIV-positive women in Ethiopia.

methodsPubMed, Google Scholar, EMBASE, HINAR, Scopus, and Web of Sciences were searched for published articles from March 2010 to March 2022. The pooled prevalence of adherence was estimated using a weighted DerSimonian-Laird random effect model. The I2 statistics was used to identify the degree of heterogeneity. Publication bias was also assessed using the funnel plot and Egger's regression test.

resultsA total of 15 studies were included. The pooled estimate of the option B+ program among HIV-positive women in Ethiopia was 81.58% (95% CI: 77.33-85.84). Getting social and financial support (AOR = 3.73, 95% CI: 2.12, 6.58), disclosure of HIV status to partners (AOR = 2.05, 95% CI: 1.75, 2.41), time to reach a health facility (AOR = 0.33, 95% CI: 0.16, 0.67), receiving counseling on drug side effects (AOR = 4.09, 95% CI: 2.74, 6.11), experience of drug side effects (AOR = 0.17, 95% CI: 0.08, 0.36), and knowledge (AOR = 4.73, 95% CI: 2.62, 8.51) were significantly associated with adherence to the Option B+ program.

conclusionThis meta-analysis showed that the level of adherence to the Option B+ program in Ethiopia is lower than the 95% level of adherence planned to be achieved in 2020. Social and financial support, disclosure of HIV status, time to reach the health facility, counseling, drug side effects, and knowledge of PMTCT were significantly associated with option B+ adherence. The findings of this meta-analysis highlight that governmental, non-governmental, and other stakeholders need to design an effective strategy to scale up the level of disclosing one's own HIV status, access health facilities, improve knowledge of PMTCT, and counsel the potential side effects of Option B+ drugs, and advocate the program to reduce the multidimensional burden of HIV/AIDS.

trial registrationProspero registration: CRD42022320947. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022320947.

Indexed as

HIV InfectionsInfectious Disease Transmission, VerticalAnti-HIV AgentsEthiopiaFemaleHumansPregnancyAnti-HIV Agents

Identifiers

PMID38662634
PMCPMC11045077
OpenAlexW4395448919

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.