Evidence map›Paper›PMID 38662574›Full record

ArticleBiochemistry2024

NMR Structure of Retinal Guanylate Cyclase Activating Protein 5 (GCAP5) with R22A Mutation That Abolishes Dimerization and Enhances Cyclase Activation.

Diana L Cudia, Effibe O Ahoulou, Aritra Bej, Annika N Janssen, Alexander Scholten, Karl-W Koch, James B Ames

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Diana L CudiaDepartment of Chemistry, University of California, Davis, Davis, California 95616, United States.
Effibe O AhoulouDepartment of Chemistry, University of California, Davis, Davis, California 95616, United States.
Aritra BejDepartment of Chemistry, University of California, Davis, Davis, California 95616, United States.
Annika N JanssenDivision of Biochemistry, Department of Neuroscience, Carl von Ossietzky Universität Oldenburg, 26129 Oldenburg, Germany.
Alexander ScholtenDivision of Biochemistry, Department of Neuroscience, Carl von Ossietzky Universität Oldenburg, 26129 Oldenburg, Germany.
Karl-W KochDivision of Biochemistry, Department of Neuroscience, Carl von Ossietzky Universität Oldenburg, 26129 Oldenburg, Germany.ORCID 0000-0003-1501-0044
James B AmesDepartment of Chemistry, University of California, Davis, Davis, California 95616, United States.ORCID 0000-0003-0934-2595

Funding

MEMBRANE TARGETING CALCIUM SENSORS IN VISIONR01EY012347 · NEI · UNIVERSITY OF MD BIOTECHNOLOGY INSTITUTE · PI AMES, JAMES B · 1999 to 2023
$6.9M
NEI NIH HHS R01 EY012347
6 · The paper itself

Abstract

Guanylate cyclase activating protein-5 (GCAP5) in zebrafish photoreceptors promotes the activation of membrane receptor retinal guanylate cyclase (GC-E). Previously, we showed the R22A mutation in GCAP5 (GCAP5

Indexed as

Guanylate CyclaseGuanylate Cyclase-Activating ProteinsModels, MolecularAnimalsCalciumEnzyme ActivationMutationNuclear Magnetic Resonance, BiomolecularProtein ConformationProtein MultimerizationRetinaZebrafishZebrafish ProteinsCalciumGuanylate CyclaseGuanylate Cyclase-Activating ProteinsZebrafish Proteins

Identifiers

PMID38662574
PMCPMC12515499

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.