Evidence map›Paper›PMID 38662551›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

TRAF3 loss-of-function reveals the noncanonical NF-κB pathway as a therapeutic target in diffuse large B cell lymphoma.

Michael Y Li, Lauren C Chong, Gerben Duns, Andrew Lytle, Bruce Woolcock, Aixiang Jiang, Adèle Telenius, Susana Ben-Neriah, Waqas Nawaz, Graham W Slack and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Michael Y LiCentre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC V5Z 1L3, Canada.
Lauren C ChongCentre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC V5Z 1L3, Canada.
Gerben DunsCentre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC V5Z 1L3, Canada.
Andrew LytleCentre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0002-9979-3690
Bruce WoolcockCentre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0002-6206-913X
Aixiang JiangCentre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0002-6153-7595
Adèle TeleniusCentre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0002-6901-5126
Susana Ben-NeriahCentre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0002-2867-4037
Waqas NawazCentre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC V5Z 1L3, Canada.
Graham W SlackCentre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC V5Z 1L3, Canada.
Ingrid ElisiaTerry Fox Laboratory, British Columbia Cancer, Vancouver, BC V5Z 1L3, Canada.
Elena ViganòCentre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC V5Z 1L3, Canada.
Tomohiro AokiCentre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC V5Z 1L3, Canada.
Shannon HealyCentre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC V5Z 1L3, Canada.
Gerald KrystalTerry Fox Laboratory, British Columbia Cancer, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0002-1961-6281
Leandro VenturuttiCentre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0002-7264-8370
David W ScottCentre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC V5Z 1L3, Canada.
Christian SteidlCentre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0001-9842-9750
Spinal Cord Injury BC · CAUniversity of British Columbia · CATerry Fox Research Institute · CA

Funding

CIHR Project Grant 180613Elizabeth C. Watters Research Fellowship N/ALeukemia and Lymphoma Society (LLS) 6663-23Leukemia and Lymphoma Society of Canada (LLSC) 6663-23Lotte and John Hecht Memorial Foundation (LJHMF) 4340Michael Smith Health Research BC (MSFHR) N/ATerry Fox Research Institute (TFRI) 1061Terry Fox Research Institute (TFRI) 1108
6 · The paper itself

Abstract

Here, we report recurrent focal deletions of the chr14q32.31-32 locus, including

Indexed as

Lymphoma, Large B-Cell, DiffuseNF-kappa BSignal TransductionTNF Receptor-Associated Factor 3CD8-Positive T-LymphocytesCell Line, TumorCell ProliferationHumansNF-kappaB-Inducing KinaseProtein Serine-Threonine KinasesNF-kappa BNF-kappaB-Inducing KinaseProtein Serine-Threonine KinasesTNF Receptor-Associated Factor 3TRAF3 protein, humanfunctional modelslymphomasomatic mutationstargeted therapiestumor microenvironment

Identifiers

PMID38662551
PMCPMC11067025
OpenAlexW4395467551

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.