Evidence map›Paper›PMID 38662222›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2024

Role of sodium fluorescein in pediatric low-grade glioma surgery: an update.

Camilla de Laurentis, Claudia Pasquali, Pierre-Aurélien Beuriat, Carmine Mottolese, Alexandru Szathmari, Matthieu Vinchon, Federico Di Rocco

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Camilla de LaurentisPediatric Neurosurgery Unit, Hôpital Femme Mère Enfant, Lyon, France.
Claudia PasqualiPediatric Neurosurgery Unit, Hôpital Femme Mère Enfant, Lyon, France.
Pierre-Aurélien BeuriatPediatric Neurosurgery Unit, Hôpital Femme Mère Enfant, Lyon, France.
Carmine MottolesePediatric Neurosurgery Unit, Hôpital Femme Mère Enfant, Lyon, France.
Alexandru SzathmariPediatric Neurosurgery Unit, Hôpital Femme Mère Enfant, Lyon, France.
Matthieu VinchonPediatric Neurosurgery Unit, Hôpital Femme Mère Enfant, Lyon, France.
Federico Di RoccoPediatric Neurosurgery Unit, Hôpital Femme Mère Enfant, Lyon, France. federico.dirocco@chu-lyon.fr.
Hospices Civils de Lyon · FRHôpital Femme Mère Enfant · FRHôpital Pierre Wertheimer · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeComplete surgical resection is still the mainstay in the treatment of central nervous system low-grade tumors, eventually resulting curative. The complete surgical removal of these lesions, however, may be difficult in some cases because of their infiltrative nature. Intraoperative adjuncts may be a game changer. Sodium fluorescein (SF) is among the ideal candidates as intraoperative tools to favor the actual recognition of the tumor extension, since it accumulates in areas of altered blood-brain barrier, a typical characteristic of pediatric gliomas, and has a low rate of adverse events. This work proposes an update of previous works about the evaluation of the feasibility and usefulness of a systematic use of SF in a low-grade lesion group of pediatric patients.

methodsPediatric patients operated on for a resection or a biopsy of a low-grade glial or glioneuronal lesion (WHO grade I and II) at our Institution between September 2021 and December 2023, with the intraoperative use of sodium fluorescein (SF), were enrolled in the study. We collected pre-operative and postoperative clinical and radiological data, intraoperative findings, and post-operative pathological diagnoses.

resultsNo adverse events were registered related to the intraoperative use of SF. SF appeared useful for the localization of boundaries of tumors, especially when characterized by a high degree of infiltration or by a deep-seated location, and for the checking of possible tumor remnants at the end of surgery. A good tumor-to-healthy tissue contrast was registered when tumor visualization was in a range between 1 to 2 h and 30 min after SF injection. Possible "false positives" due to intraoperative vascular wall injury and clearance of SF from both tumor and healthy tissue were observed in some cases and still remain open issues.

conclusionsSF is a feasible and safe intraoperative adjunct tool in the surgical removal of pediatric low-grade tumors. SF may show its usefulness especially in selected cases, such as deep-seated lesions and infiltrating tumors. Its safety profile, user-friendly management, and potential utility in both tumor resections and neuronavigated biopsies favor its wider use in the surgical treatment of pediatric low-grade tumors.

Indexed as

Brain NeoplasmsFluoresceinGliomaAdolescentChildChild, PreschoolFemaleFluorescent DyesHumansInfantMaleNeurosurgical ProceduresFluoresceinFluorescent DyesFluorophoreLow-grade glioneuronal tumorsPediatric neuro-oncologyPilocytic astrocytomaYELLOW 560 nm filter

Identifiers

PMID38662222
OpenAlexW4395465817

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.