Evidence map›Paper›PMID 38662122›Full record

ArticleAnnals of biomedical engineering2024

Modified Titanium Surface with Nano Amorphous Calcium Phosphate@Chitosan Oligolactate as Ion Loading Platform with Multifunctional Properties for Potential Biomedical Application.

Marijana R Pantović Pavlović, Nenad L Ignjatović, Senka Gudić, Ladislav Vrsalović, Katarina Đ Božić, Marko E Popović, Miroslav M Pavlović

Abstract read
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In one paragraph

Article in Annals of biomedical engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Marijana R Pantović PavlovićDepartment of Electrochemistry, Institute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11000, Serbia.ORCID http://orcid.org/0000-0002-9507-3469
Nenad L IgnjatovićInstitute of Technical Sciences of the Serbian Academy of Sciences and Arts, Belgrade, 11000, Serbia.ORCID http://orcid.org/0000-0002-5749-094X
Senka GudićFaculty of Chemistry and Technology, University of Split, 21000, Split, Croatia.ORCID http://orcid.org/0000-0001-5390-5215
Ladislav VrsalovićFaculty of Chemistry and Technology, University of Split, 21000, Split, Croatia.ORCID http://orcid.org/0000-0001-6111-5475
Katarina Đ BožićDepartment of Electrochemistry, Institute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11000, Serbia.ORCID http://orcid.org/0000-0002-6712-0221
Marko E PopovićDepartment of Electrochemistry, Institute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11000, Serbia.ORCID http://orcid.org/0000-0003-0934-5550
Miroslav M PavlovićDepartment of Electrochemistry, Institute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia, University of Belgrade, Belgrade, 11000, Serbia. miroslav.pavlovic@ihtm.bg.ac.rs.ORCID http://orcid.org/0000-0003-3754-4143
University of Belgrade · RSUniversity of Split · HRSerbian Academy of Sciences and Arts · RS

Funding

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 451-03-47/2023-01/200026Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 451-03-66/2024-03/200175
6 · The paper itself

Abstract

Titanium (Ti) is widely used in medical and dental implants. Calcium phosphate (CPs) coatings enhance Ti implants' osteoinductive properties, and additives further improve these coatings. Recently, a nano amorphous calcium phosphate (nACP) coating decorated with chitosan oligolactate (ChOL) and selenium (Se) showed immunomodulatory effects. This study investigates the surface morphology, composition, bioactivity, mechanical properties, and Se-release mechanism of the nACP@ChOL-Se hybrid coating on Ti substrates. Amorphous calcium phosphate (ACP) was synthesized, and the nACP@ChOL-Se hybrid coating was deposited on Ti substrates using in situ anaphoretic deposition. Physico-chemical characterization was used to analyze the surface of the coating (scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier Transform Infrared Spectroscopy). The distribution of Se within the coating was examined with energy-dispersive X-ray spectroscopy (EDS). Bioactivity was evaluated in simulated body fluid (SBF), and adhesion was tested using a scratch test method. In vitro testing determined the release mechanism of Se. SEM images illustrated the surface morphology, while AFM provided a detailed analysis of surface roughness. XRD analysis revealed structural and phase composition, and EDS confirmed Se distribution within the coating. The coating exhibited bioactivity in SBF and showed good adhesion according to the scratch test. In vitro testing uncovered the release mechanism of Se from the coating. This study successfully characterized the surface morphology, composition, bioactivity, and Se-release mechanism of the nACP@ChOL-Se hybrid coating on Ti substrates, offering insights for developing immunomodulatory coatings for medical and dental applications.

Indexed as

Calcium PhosphatesChitosanCoated Materials, BiocompatibleSeleniumTitaniumSurface Propertiesamorphous calcium phosphateCalcium PhosphatesChitosanCoated Materials, BiocompatibleSeleniumTitaniumBioactivityHybrid coatingImplantsIon releaseNano calcium phosphate

Identifiers

PMID38662122
OpenAlexW4395466128

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.