Evidence map›Paper›PMID 38661548›Full record

ArticleJournal of neurotrauma2024

White Matter Hyperintensities and Microstructural Alterations in Contact Sport Athletes from Adolescence to Early Midlife.

Benjamin L Brett, Andrew Klein, Parsia Vazirnia, Samantha Omidfar, Kevin Guskiewicz, Michael A McCrea, Timothy B Meier

Open access · greenAbstract read
In one paragraph

Article in Journal of neurotrauma, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Benjamin L BrettDepartments of Neurosurgery and Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0000-0003-2849-4658
Andrew KleinDepartment of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Parsia VazirniaDepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Samantha OmidfarDepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Kevin GuskiewiczDepartment of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Michael A McCreaDepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Timothy B MeierDepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0000-0002-4495-2754
Medical College of Wisconsin · USUniversity of North Carolina at Chapel Hill · US

Funding

The role of neuroactive kynurenine metabolites in the chronic sequelae of concussion and contact sport exposureR01NS102225 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI MEIER, TIMOTHY B. · 2018 to 2022
$1.8M
The effects of cumulative concussion, repetitive head impacts, and comorbid cardiovascular risk factors on MRI metrics of pathological aging and neurobehavioral functioning across the lifespanK23AG073528 · NIA · MEDICAL COLLEGE OF WISCONSIN · PI BRETT, BENJAMIN L · 2021 to 2025
$661k
NIA NIH HHS K23 AG073528NINDS NIH HHS L30 NS113158NINDS NIH HHS R01 NS102225
6 · The paper itself

Abstract

Studies have demonstrated associations between cumulative concussion and repetitive head impact exposure (RHI) through contact sports with white matter (WM) alterations later in life. The course of WM changes associated with exposure earlier in the lifespan is unclear. This study investigated alterations in white matter (WM hyperintensity [WMH] volume and microstructural changes) associated with concussion and RHI exposure from adolescence to early midlife, as well as the interaction between exposure and age cohort (i.e., adolescent/young adult compared with early midlife athlete cohorts) on WM outcomes. Participating football players included an adolescent/young adulthood cohort (

Indexed as

AthletesBrain ConcussionFootballWhite MatterAdolescentAdultAthletic InjuriesCohort StudiesHumansMagnetic Resonance ImagingMaleYoung Adultconcussiondiffusion MRINODDIrepetitive head impactswhite matter hyperintensitieswhite matter microstructure

Identifiers

PMID38661548
PMCPMC11564850
OpenAlexW4395465615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.