Evidence map›Paper›PMID 38661511›Full record

Observational studyJournal of the European Academy of Dermatology and Venereology : JEADV2025

Obesity is linked to disease severity in moderate to severe atopic dermatitis-Data from the prospective observational TREATgermany registry.

Stephan Traidl, Moritz M Hollstein, Nadine Kroeger, Sascha Fischer, Annice Heratizadeh, Luise Heinrich, Barbara Kind, Doreen Siegels, Susanne Abraham, Thomas Schäfer and 20 more

Open access · hybridAbstract readObservational Study
In one paragraph

Observational study in Journal of the European Academy of Dermatology and Venereology : JEADV, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. New bricks in the wall regarding the link between obesity and atopic dermatitis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025
    Article
  5. Observational
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 20 institutions in 1 country.

Stephan TraidlDepartment of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0003-4806-599X
Moritz M HollsteinDepartment of Dermatology, Venereology and Allergology, University Medical Centre Göttingen, Göttingen, Germany.
Nadine KroegerDepartment of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Sascha FischerDepartment of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Annice HeratizadehDepartment of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Luise HeinrichCenter for Evidence-Based Healthcare, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universitaet Dresden, Dresden, Germany.
Barbara KindCenter for Evidence-Based Healthcare, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universitaet Dresden, Dresden, Germany.
Doreen SiegelsCenter for Evidence-Based Healthcare, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universitaet Dresden, Dresden, Germany.ORCID https://orcid.org/0000-0002-4049-9120
Susanne AbrahamDepartment of Dermatology, University Allergy Center, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany.ORCID https://orcid.org/0000-0001-7457-6481
Thomas SchäferPractice Dr. med. Thomas Schaefer/Dr. med. Doreen Belz, Derma Koeln, Koeln, Germany.
Matthias AugustinInstitute for Health Services Research in Dermatology Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0002-4026-8728
Inken HarderCenter for Inflammatory Skin Diseases, Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Andreas PinterDepartment of Dermatology, Venereology and Allergology, Clinical Research, University Hospital, Frankfurt am Main, Germany.ORCID https://orcid.org/0000-0002-1330-1502
Knut SchäkelDepartment of Dermatology, Ruprecht-Karls University Heidelberg, Heidelberg, Germany.ORCID https://orcid.org/0000-0001-6344-7799
Andreas WollenbergDepartment of Dermatology and Allergy, Ludwig Maximilian University, Munich, Germany.ORCID https://orcid.org/0000-0003-0177-8722
Konstantin ErtnerPractice Dr. med. Konstantin Ertner, Nuernberg, Germany.
Jutta Ramaker-BrunkePractice 'Die Hautärzte' Braunschweig, Braunschweig, Germany.
Anne BongPractice Dr. med. Anne Bong, Emmerich, Germany.
Sven QuistDermatology Clinic, Helix Medical Excellence Center Mainz, Mainz, Germany.
Hannah Gorriahn-MaiterthPractice Dermasana, Karlsruhe, Germany.
Florian SchenckDermatology Center, Hannover, Germany.
Michael SticherlingDepartment of Dermatology, University, German Center for Immunotherapy, Erlangen, Germany.
Isaak EffendyDepartment of Dermatology Venereology and Allergology, University Hospital - Medical School OWL - University of Bielefeld, Rosenhoehe, Bielefeld, Germany.
Beate SchwarzPractice Dr. med. Beate Schwarz, Langenau, Germany.
Christiane HandrickPractice Dr. med. Christiane Handrick, Berlin, Germany.
Andrea AsmussenPractice Dr. med. Andrea Asmussen, Dermatology at Lesum, Bremen, Germany.
Stephan WeidingerCenter for Inflammatory Skin Diseases, Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Jochen SchmittCenter for Evidence-Based Healthcare, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universitaet Dresden, Dresden, Germany.
Thomas WerfelDepartment of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
TREATgermany Study Group
Medizinische Hochschule Hannover · DEUniversity Hospital Carl Gustav Carus · DEUniversity Hospital Schleswig-Holstein · DEBielefeld University · DEGerman Center for Neurodegenerative Diseases · DEGoethe University Frankfurt · DEHannover Re (Germany) · DEHanover University of Music Drama and Media · DEHeidelberg University · DEHelmholtz Institute Mainz · DEKarlsruhe University of Education · DEKlinikum Braunschweig · DEParacelsus Medizinische Privatuniversität · DERohde & Schwarz (Germany) · DERoland Mills United (Germany) · DESt. Anna Hospital · DETH Köln - University of Applied Sciences · DEUniversität Hamburg · DEUniversity Hospital Augsburg · DEUniversity of Göttingen · DE

Funding

AbbVie Deutschland GmbH & CoGalderma S.A.LEO Pharma GmbHLilly Deutschland GmbHPfizer Inc.Sanofi
6 · The paper itself

Abstract

backgroundThere are conflicting data on a potential association between obesity and atopic dermatitis (AD). The purpose of this study was to investigate the relationship between obesity and AD disease severity.

methodsPatients from the TREATgermany registry cohort were divided into three groups according to their body mass index (BMI). Due to low numbers, underweight patients (BMI <18.5 kg/m

resultsThis study encompassed 1416 patients, of which 234 (16.5%) were obese (BMI ≥30 kg/m DISCUSSION: In this large and well-characterized AD patient cohort, obesity is significantly associated with physician- and patient-assessed measures of AD disease severity. However, the corresponding effect sizes were low and of questionable clinical relevance. The overall prevalence of obesity among the German AD patients was lower than in studies on other AD cohorts from different countries, which confirms previous research on the German population and suggests regional differences in the interdependence of AD and obesity prevalence.

Indexed as

Body Mass IndexDermatitis, AtopicObesityRegistriesSeverity of Illness IndexAdultFemaleGermanyHumansMaleMiddle AgedProspective Studies

Identifiers

PMID38661511
PMCPMC11664465
OpenAlexW4395465825

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.