ReviewACS sensors2024
Beyond the Gold-Thiol Paradigm: Exploring Alternative Interfaces for Electrochemical Nucleic Acid-Based Sensing.
Review in ACS sensors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Miniaturization of Aptasensors in Organic Electrochemical Transistors for Sensitivity Enhancement.Analytical chemistry · 2026Article
- Ultra-Thin and Highly Insulating Aromatic Monolayers by N-Heterocyclic Carbenes.Angewandte Chemie (International ed. in English) · 2026Article
- Magnetic Beads-Based Electrochemical Label-Free DNA-Bioassay for the Detection of Peanut Allergen Ara h2 in Food Matrices.Biosensors · 2026Article
- Application of Aptamer-Carbon Surfaces for Electrochemical Label-Free Detection of Vancomycin.Biosensors · 2026Article
- Mechanically Induced Switching Between Orbital- and Fano-Resonance Rectification in a Dual-Anchored Molecular Junction.Angewandte Chemie (International ed. in English) · 2026Article
- Low-Cost Polyphenol-Polypyrrole Molecularly Imprinted Sensor for Point-of-Care Alzheimer's Detection.ACS sensors · 2025Article
- Microneedle-Based Multiplexed Monitoring of Diabetes Biomarkers: Capabilities Beyond Glucose Toward Closed-Loop Theranostic Systems.ACS sensors · 2025Review
- Reproducibly Modified Elastin-like Polymer Gold Electrode Surfaces.ACS measurement science au · 2025Article
- Towards an Implantable Aptamer Biosensor for Monitoring in Inflammatory Bowel Disease.Biosensors · 2025Article
- Ultra-thin inorganic oxide and nitride films as an alternative blocking layer for electrochemical sensors.Thin solid films · 2025Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleic acid-based electrochemical sensors (NBEs) use oligonucleotides as affinity reagents for the detection of a variety of targets, ranging from small-molecule therapeutics to whole viruses. Because of their versatility in molecular sensing, NBEs are being developed broadly for diagnostic and biomedical research applications. Benchmark NBEs are fabricated via self-assembly of thiol-based monolayers on gold. Although robust for rapid prototyping, thiol monolayers suffer from limitations in terms of stability under voltage modulation and in the face of competitive ligands such as thiolated molecules naturally occurring in biofluids. Additionally, gold cannot be deployed as an NBE substrate for all biomedical applications, such as in cases where molecular measurements coupled to real-time, under-the-sensor tissue imaging is needed. Seeking to overcome these limitations, the field of NBEs is pursuing alternative ligands and electrode surfaces. In this perspective, I discuss new interface fabrication strategies that have successfully achieved NBE sensing, or that have the potential to allow NBE sensing on conductive surfaces other than gold. I hope this perspective will provide the reader with a fresh view of how future NBE interfaces could be constructed and will serve as inspiration for the pursuit of collaborative developments in the field of NBEs.
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