Evidence map›Paper›PMID 38661244›Full record

ArticleHead & neck2024

Masseter muscle thickness is predictive of cancer cachexia in patients with head and neck cancer.

Julián Balanta-Melo, Alexander J Jones, Leah J Novinger, Michael G Moore, Andrea Bonetto

Open access · greenAbstract read
In one paragraph

Article in Head & neck, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Julián Balanta-MeloDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-0138-9199
Alexander J JonesDepartment of Otolaryngology - Head & Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-9219-285X
Leah J NovingerDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0002-9018-7838
Michael G MooreDepartment of Otolaryngology - Head & Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Andrea BonettoDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID 0000-0002-3235-1871
Indiana University School of MedicineUniversity of Colorado Cancer Center · US

Funding

Treating recurrent HNSCC with radiation and dual TGF-Beta/PD-L1.P50CA261605 · NCI · UNIVERSITY OF COLORADO DENVER · PI JIMENO, ANTONIO, WANG, XIAO-JING · 2021 to 2025
$10.1M
Targeting RANKL for the treatment of muscle and bone defects in cachexiaR01AR079379 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Andrea Bonetto · 2021 to 2026
$2.1M
IGFBP1 mediates a liver-bone-muscle axis in colorectal cancer cachexiaR01AR080051 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Andrea Bonetto · 2022 to 2026
$2.1M
American Cancer Society 132013-RSG-18-010-01-CCGIndiana Center for Musculoskeletal HealthNCI NIH HHS P50 CA261605NCI NIH HHS P50CA261605NIAMS NIH HHS R01 AR079379NIAMS NIH HHS R01AR079379NIAMS NIH HHS R01 AR080051NIAMS NIH HHS R01AR080051
6 · The paper itself

Abstract

backgroundCancer cachexia is prevalent in head and neck cancer patients. The L3 skeletal muscle index (SMI) is often used to assess sarcopenia and cachexia but is infrequently able to be measured in this population. Masseter muscle thickness (MT) may serve as an alternative predictor of cachexia.

methodsSMI and MT were calculated from 20 trauma (CTRL) and 40 cachectic (CA-CX) and non-cachectic (CA-NCX) head and neck cancer patients. Area Under the Curve of the Receiver Operating Characteristics (AUC-ROC) analysis was performed for SMI and MT.

resultsBoth SMI and MT were significantly decreased in CA-CX patients (vs. CA-NCX mean difference -19.5 cm

conclusionsCompared with SMI, MT is a good alternative prognostic biomarker to determine CA-CX status in HNC patients.

Indexed as

CachexiaHead and Neck NeoplasmsMasseter MuscleAdultAgedFemaleHumansMaleMiddle AgedPredictive Value of TestsPrognosisROC CurveSarcopeniacachexiahead and neck cancermasticatory musclessarcopeniaskeletal muscle

Identifiers

PMID38661244
PMCPMC11473234
OpenAlexW4395464409

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.