Tgif1-deficiency impairs cytoskeletal architecture in osteoblasts by activating PAK3 signaling.

Simona Bolamperti, Hiroaki Saito, Sarah Heerdmann, Eric Hesse, Hanna Taipaleenmäki

Open access · goldAbstract read

In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.2field-weighted citation impact, top 47% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Simona BolampertiMolecular Skeletal Biology Laboratory, Department of Trauma Surgery and Orthopedics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0002-8940-8859

Hiroaki SaitoMolecular Skeletal Biology Laboratory, Department of Trauma Surgery and Orthopedics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Sarah HeerdmannMolecular Skeletal Biology Laboratory, Department of Trauma Surgery and Orthopedics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Eric Hesse *Molecular Skeletal Biology Laboratory, Department of Trauma Surgery and Orthopedics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0002-2778-7208

Hanna Taipaleenmäki *Molecular Skeletal Biology Laboratory, Department of Trauma Surgery and Orthopedics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0002-8254-9333

Universität Hamburg · DE

Funding

AO Foundation S-13-73HDeutsche Forschungsgemeinschaft HE 5208/2-1Deutsche Forschungsgemeinschaft HE 5208/2-3Deutsche Forschungsgemeinschaft HE 5208/3-1Deutsche Forschungsgemeinschaft TA 1154/1-1Deutsche Forschungsgemeinschaft TA 1154/1-2European Calcified Tissue Society ECTSABBF2015_0019European Commission PCIG10-GA-2011-303722

6 · The paper itself

Abstract

Osteoblast adherence to bone surfaces is important for remodeling bone tissue. This study demonstrates that deficiency of TG-interacting factor 1 (Tgif1) in osteoblasts results in altered cell morphology, reduced adherence to collagen type I-coated surfaces, and impaired migration capacity. Tgif1 is essential for osteoblasts to adapt a regular cell morphology and to efficiently adhere and migrate on collagen type I-rich matrices in vitro. Furthermore, Tgif1 acts as a transcriptional repressor of p21-activated kinase 3 (

Indexed as

CytoskeletonHomeodomain ProteinsOsteoblastsp21-Activated KinasesRepressor ProteinsSignal TransductionAnimalsCell AdhesionCell MovementMiceHomeodomain Proteinsp21-Activated KinasesPak3 protein, mouseRepressor ProteinsTgif1 protein, mousebone regenerationcell biologymouseosteoblast spreadingPAK3PTHTgif1

Identifiers

PMID38661167

DOI10.7554/eLife.94265

PMCPMC11045221

OpenAlexW4390940947

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.