Evidence map›Paper›PMID 38661008›Full record

ArticleJournal of cell science2024

Non-canonical role for the BAF complex subunit DPF3 in mitosis and ciliogenesis.

Giulia Verrillo, Anna Maria Obeid, Alexia Genco, Jacopo Scrofani, François Orange, Sarah Hanache, Julien Mignon, Tanguy Leyder, Catherine Michaux, Céline Kempeneers and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. The Zinc Finger Ran-Binding Protein 3 (ZRANB3): An Advanced Perspective.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Giulia VerrilloUniversity of Liege, GIGA - Research Institute, Molecular Analysis of Gene Expression (MAGE) Laboratory, B34, Avenue de l'Hôpital, B-4000 Liège, Belgium.ORCID 0009-0008-2014-2352
Anna Maria ObeidUniversity of Liege, GIGA - Research Institute, Molecular Analysis of Gene Expression (MAGE) Laboratory, B34, Avenue de l'Hôpital, B-4000 Liège, Belgium.
Alexia GencoUniversity of Liege, GIGA - Research Institute, Molecular Analysis of Gene Expression (MAGE) Laboratory, B34, Avenue de l'Hôpital, B-4000 Liège, Belgium.
Jacopo ScrofaniCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona 08003, Spain.
François OrangeUniversité Côte d'Azur, Centre Commun de Microscopie Appliquée (CCMA), 06100 Nice, France.
Sarah HanacheUniversity of Liege, GIGA - Research Institute, Molecular Analysis of Gene Expression (MAGE) Laboratory, B34, Avenue de l'Hôpital, B-4000 Liège, Belgium.
Julien MignonUniversity of Namur, Laboratory of Physical Chemistry of Biomolecules, Unité de Chimie Physique Théorique et Structurale (UCPTS), Rue de Bruxelles 61, B-5000 Namur, Belgium.
Tanguy LeyderUniversity of Namur, Laboratory of Physical Chemistry of Biomolecules, Unité de Chimie Physique Théorique et Structurale (UCPTS), Rue de Bruxelles 61, B-5000 Namur, Belgium.
Catherine MichauxUniversity of Namur, Laboratory of Physical Chemistry of Biomolecules, Unité de Chimie Physique Théorique et Structurale (UCPTS), Rue de Bruxelles 61, B-5000 Namur, Belgium.
Céline KempeneersUniversity of Liege, Pneumology Laboratory, I3 Group, GIGA Research Center, B-4000 Liège, Belgium.
Noëmie BricmontUniversity of Liege, Pneumology Laboratory, I3 Group, GIGA Research Center, B-4000 Liège, Belgium.
Stephanie HerkenneUniversity of Liege, GIGA-Cancer, Laboratory of Mitochondria and Cell Communication, B34, Avenue de l'Hôpital, B-4000 Liège, Belgium.
Isabelle VernosCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona 08003, Spain.
Maud MartinLaboratory of Neurovascular Signaling, Department of Molecular Biology, ULB Neuroscience Institute, Université libre de Bruxelles, B-6041 Gosselies, Belgium.
Denis MottetUniversity of Liege, GIGA - Research Institute, Molecular Analysis of Gene Expression (MAGE) Laboratory, B34, Avenue de l'Hôpital, B-4000 Liège, Belgium.ORCID 0000-0001-5410-1593
University of Liège · BEUniversity of Namur · BECentre for Genomic Regulation · ESInstitució Catalana de Recerca i Estudis Avançats · ESUniversité Côte d'Azur · FRUniversité Libre de Bruxelles · BE

Funding

FNRS (Fonds National de la Recherche Scientifique), BelgiumFonds De La Recherche Scientifique - FNRSFonds Léon FredericqFonds Speciaux de la Recherche de l'Universite de LiegeFonds Spéciaux de RechercheGeneralitat de Catalunya AGAUR-SGR 478GIS-IBiSAMinisterio de Ciencia, Innovación y Universidades PGC2018-096976-B-I00Ministerio de Economía y Competitividad BFU2015-68726-PMinistry of Science, Innovation and Universities PGC2018-096976-B-I00Region Sud-Provence-Alpes-Cote d'AzurSanofiSpanish Ministry of Economy BFU2015-68726-PTéléviethe Conseil General des Alpes Maritimes
6 · The paper itself

Abstract

DPF3, along with other subunits, is a well-known component of the BAF chromatin remodeling complex, which plays a key role in regulating chromatin remodeling activity and gene expression. Here, we elucidated a non-canonical localization and role for DPF3. We showed that DPF3 dynamically localizes to the centriolar satellites in interphase and to the centrosome, spindle midzone and bridging fiber area, and midbodies during mitosis. Loss of DPF3 causes kinetochore fiber instability, unstable kinetochore-microtubule attachment and defects in chromosome alignment, resulting in altered mitotic progression, cell death and genomic instability. In addition, we also demonstrated that DPF3 localizes to centriolar satellites at the base of primary cilia and is required for ciliogenesis by regulating axoneme extension. Taken together, these findings uncover a moonlighting dual function for DPF3 during mitosis and ciliogenesis.

Indexed as

CiliaMitosisTranscription FactorsAnimalsAxonemeCentriolesCentrosomeDNA-Binding ProteinsGenomic InstabilityHeLa CellsHumansKinetochoresMiceSpindle ApparatusDNA-Binding ProteinsTranscription FactorsBridging fiberCentriolar satellitesChromosome alignmentCiliogenesisDPF3Genomic instabilityMitosis

Identifiers

PMID38661008
PMCPMC11166463
OpenAlexW4395453181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.