Evidence map›Paper›PMID 38660940›Full record

ArticleeLife2024

Unraveling the link between neuropathy target esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier.

Mariana I Tsap, Andriy S Yatsenko, Jan Hegermann, Bibiana Beckmann, Dimitrios Tsikas, Halyna R Shcherbata

Open access · goldAbstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Fly · 2026
    Review
  2. Review
  3. Article
  4. International journal of molecular sciences · 2026
    Article
  5. International journal of molecular sciences · 2025
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Mariana I TsapInstitute of Cell Biochemistry, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0009-0006-0891-8504
Andriy S YatsenkoInstitute of Cell Biochemistry, Hannover Medical School, Hannover, Germany.
Jan HegermannInstitute of Functional and Applied Anatomy, Research Core Unit Electron Microscopy, Hannover Medical School, Hannover, Germany.
Bibiana BeckmannInstitute of Toxicology, Hannover Medical School, Hannover, Germany.
Dimitrios TsikasInstitute of Toxicology, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0001-6320-0956
Halyna R ShcherbataInstitute of Cell Biochemistry, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0000-0002-3855-0345
Medizinische Hochschule Hannover · DEMount Desert Island Biological Laboratory · US

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI JAMES A COFFMAN · 2012 to 2026
$60.0M
Understanding the role of thyroid hormone signaling during axolotl limb regenerationP20GM104318 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI DRUMMOND, IAIN A. · 2013 to 2023
$23.0M
Deutsche Forschungsgemeinschaft 521749003Deutsche Forschungsgemeinschaft INST 192/574-1 FUGGEuropean Molecular Biology Organization Young Investigator ProgrammeNIGMS NIH HHS P20 GM103423NIGMS NIH HHS P20 GM104318Volkswagen Foundation 90218Volkswagen Foundation 97750
6 · The paper itself

Abstract

Mutations in

Indexed as

Blood-Brain BarrierCarboxylic Ester HydrolasesFatty AcidsInflammationNeurogliaAnimalsDrosophila melanogasterDrosophila ProteinsHumansLysosomal Storage DiseasesCarboxylic Ester HydrolasesDrosophila ProteinsFatty Acidsneurotoxic esterasebrain-blood barriercell biologyD. melanogasterfree fatty acidsinflammationlysosomal storage diseasesneurodegenerationneuroscienceNTE/SWS neuropathy target esterase

Identifiers

PMID38660940
PMCPMC11090517
OpenAlexW4395454199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.