Evidence map›Paper›PMID 38660794›Full record

Trial reportCirculation. Cardiovascular interventions2024

Three-Year Clinical Impact of Murray Law-Based Quantitative Flow Ratio and OCT- or FFR-Guidance in Angiographically Intermediate Coronary Lesions.

Cristina Aurigemma, Daixin Ding, Shengxian Tu, Chunming Li, Wei Yu, Yingguang Li, Antonio Maria Leone, Enrico Romagnoli, Rocco Vergallo, Alessandro Maino and 3 more

Registry-linked trialAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation. Cardiovascular interventions, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01824030 (FFR or OCT Guidance to RevasculariZe Intermediate Coronary Stenosis Using Angioplasty), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01824030 phase3unknown statusnot on this map

FFR or OCT Guidance to RevasculariZe Intermediate Coronary Stenosis Using Angioplasty

TypeinterventionalSponsorCatholic University of the Sacred HeartRan2013 to 2016Enrolled400ConditionsIschemic Heart DiseaseArmsFFR guided PCI, OCT guided PCI
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cristina Aurigemma *Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy (C.A., E.R., R.V., C.T., F.B.).ORCID 0000-0001-6391-422X
Daixin Ding *Lambe Institute for Translational Research, Smart Sensors Laboratory and Curam, University of Galway, Ireland (D.D., W.W.).
Shengxian TuDepartment of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China (D.D., S.T.).ORCID 0000-0001-9681-1067
Chunming LiBiomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, China (S.T., C.L., W.Y., Y.L.).ORCID 0000-0003-1187-2835
Wei YuBiomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, China (S.T., C.L., W.Y., Y.L.).ORCID 0000-0002-3135-0148
Yingguang LiBiomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, China (S.T., C.L., W.Y., Y.L.).ORCID 0000-0003-3907-4309
Antonio Maria LeoneOspedale Fatebenefratelli Isola Tiberina Gemelli Isola Roma, Italia (A.M.L.).ORCID 0000-0002-1276-9883
Enrico RomagnoliFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy (C.A., E.R., R.V., C.T., F.B.).ORCID 0000-0003-1611-7708
Rocco VergalloFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy (C.A., E.R., R.V., C.T., F.B.).ORCID 0000-0001-5577-081X
Alessandro MainoUniversità Cattolica del Sacro Cuore, Rome, Italy (A.M., C.T., F.B.).ORCID 0000-0002-3219-8336
Carlo TraniFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy (C.A., E.R., R.V., C.T., F.B.).ORCID 0000-0001-9777-013X
William WijnsLambe Institute for Translational Research, Smart Sensors Laboratory and Curam, University of Galway, Ireland (D.D., W.W.).ORCID 0000-0002-7267-4376
Francesco BurzottaFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy (C.A., E.R., R.V., C.T., F.B.).ORCID 0000-0002-6569-9401

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe FORZA trial (FFR or OCT Guidance to Revascularize Intermediate Coronary Stenosis Using Angioplasty) prospectively compared the use of fractional flow reserve (FFR) or optical coherence tomography (OCT) for treatment decisions and percutaneous coronary intervention (PCI) optimization in patients with angiographically intermediate coronary lesions. Murray law-based quantitative-flow-ratio (μQFR) is a novel noninvasive method for the computation of FFR. In the present study, we evaluated the clinical impact of μQFR, FFR, or OCT guidance in FORZA trial lesions at 3-year follow-up.

methodsμQFR was assessed at baseline and, in the case of a decision to intervene, after (FFR- or OCT-guided) PCI. The baseline μQFR was considered the final μQFR for deferred lesions, and post-PCI μQFR value was taken as final for stented lesions. The primary end point was target vessel failure ([TVF]; cardiac death, target-vessel-related myocardial infarction, and target-vessel-revascularization) at a 3-year follow-up.

resultsA total of 419 vessels (199 OCT-guided and 220 FFR-guided) were included in the FORZA trial. μQFR was evaluated in 256 deferred lesions and 159 treated lesions (98 OCT-guided PCI and 61 FFR-guided PCI). In treated lesions, post-PCI μQFR was higher in OCT-group compared with FFR-group (median, 0.93 versus 0.91;

conclusionsIn vessels with angiographically intermediate coronary lesions, OCT-guided PCI resulted in comparable clinical outcomes as FFR-guided PCI. μQFR estimated at the end of diagnostic or interventional procedure predicted 3-year TVF. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01824030.

Indexed as

Coronary AngiographyCoronary StenosisCoronary VesselsFractional Flow Reserve, MyocardialPercutaneous Coronary InterventionPredictive Value of TestsTomography, Optical CoherenceAgedCardiac CatheterizationClinical Decision-MakingCoronary Artery DiseaseFemaleHumansMaleMiddle AgedProspective Studiesfractional flow reserveoptical coherence tomographypercutaneous coronary interventionquantitative flow ratio

Identifiers

PMID38660794
PMCPMC11268551

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.