ArticleJournal of applied physiology (Bethesda, Md. : 1985)2024
Effect of obesity on sleep apnea pathogenesis differs in women versus men: multiple mediation analyses in the retrospective SNOOzzzE cohort.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 17 citations in OpenAlex.
- Combination Drug Therapy with Acetazolamide, Eszopiclone ± Venlafaxine for Obstructive Sleep Apnea (RESCUE-Combo): A Randomized, Double-Blind, Placebo-controlled Clinical Trial.Annals of the American Thoracic Society · 2025Trial
- Event duration, endotypes and hypoxic burden in obstructive sleep apnoea.ERJ open research · 2026Article
- Sleep and obesity-known interactions and open questions.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Review
- Review
- Association Between Sleep Apnea Symptoms Subtypes and Obesity.Journal of clinical medicine · 2026Article
- Hope or hype? Obesity management medications and real-world obstructive sleep apnea outcomes.Annals of the American Thoracic Society · 2026Article
- Intermittent Hypoxia-Induced Inflammation and the Formation of Exhaled Volatile Organic Compound Profiles in Obstructive Sleep Apnea-Hypopnea Syndrome: A Narrative Review.Nature and science of sleep · 2026Review
- Body Mass Index and Hypoglossal Nerve Stimulation Outcomes: A Systematic Review and Meta-Analysis.Laryngoscope investigative otolaryngology · 2025Review
- Site of Collapse during Drug-induced Sleep Endoscopy Is Associated with Polysomnographic Endotypic Traits: An Observational Study.Annals of the American Thoracic Society · 2025Observational
- Research Priorities for Translating Endophenotyping of Adult Obstructive Sleep Apnea to the Clinic: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2025Article
- Is Obstructive Sleep Apnea in People Without Obesity a Unique Disease?Archivos de bronconeumologia · 2025Article
- Obstructive sleep apnea severity and pathophysiological traits in overlap syndrome: Insights from the SNOOzzzE cohort.Physiological reports · 2025Article
- Demographic and modifiable risk factors impacting obstructive sleep apnea comorbidities: a New Orleans case-control study.Sleep & breathing = Schlaf & Atmung · 2025Article
- The relationship between obesity and obstructive sleep apnea in four community-based cohorts: an individual participant data meta-analysis of 12,860 adults.EClinicalMedicine · 2025Article
- The mediating role of BMI in the relationship between OSAHS and bone metabolism in male patients with T2DM.Sleep & breathing = Schlaf & Atmung · 2025Article
- Forty Percent and Rising - Why Every Specialist Must Care about Obesity.NEJM evidence · 2025Article
- Non-linear association between weight-adjusted-waist index and obstructive sleep apnea: a cross-sectional study from the NHANES (2005-2008 to 2015-2020).Frontiers in public health · 2025Article
- The impact of obesity on upper airway anatomy as assessed by magnetic resonance imaging and obstructive sleep apnea endotypic traits.Frontiers in physiology · 2025Article
- The Association of Body Mass Index and Adiposity-Estimating Equations with Measures of Obstructive Sleep Apnea Severity: A Cross-Sectional Study.Nature and science of sleep · 2025Article
- The Relationship Between Education Level and the Prevalence and Medical Behavior of Sleep-Disordered Breathing: A Population-Based Cross-Sectional Study.Nature and science of sleep · 2025Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
There are multiple mechanisms underlying obstructive sleep apnea (OSA) development. However, how classic OSA risk factors such as body mass index (BMI) and sex portend to OSA development has not been fully described. Thus we sought to evaluate how obesity leads to OSA and assess how these mechanisms differ between men and women. The San Diego Multi-Outcome OSA Endophenotype (SNOOzzzE) cohort includes 3,319 consecutive adults who underwent a clinical in-laboratory polysomnography at the University of California, San Diego, sleep clinic between January 2017 and December 2019. Using routine polysomnography signals, we determined OSA endotypes. We then performed mediation analyses stratified by sex to determine how BMI influenced the apnea-hypopnea index (AHI) using OSA pathophysiological traits as mediators, adjusting for age, race, and ethnicity. We included 2,146 patients of whom 919 (43%) were women and 1,227 (57%) were obese [body mass index (BMI) > 30 kg/m
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.