ArticleBrain communications2024
Histologic tau lesions and magnetic resonance imaging biomarkers differ across two progressive supranuclear palsy variants.
Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Article
- Early subtypes and progressions of progressive supranuclear palsy: a data-driven brain bank study.Journal of neurology · 2025Article
- Relationships between neuronal loss, age of death, disease duration and MRI brain volumes in progressive supranuclear palsy.Parkinsonism & related disorders · 2025Article
- Differences in neuropsychological performance across clinical variants of progressive supranuclear palsy.Journal of the International Neuropsychological Society : JINS · 2025Article
- Longitudinal assessment of white matter alterations in progressive supranuclear palsy variants using diffusion tractography.Parkinsonism & related disorders · 2025Article
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Authors and funding
17 authors at 3 institutions in 2 countries.
Funding
Abstract
Progressive supranuclear palsy is a neurodegenerative disease characterized by the deposition of four-repeat tau in neuronal and glial lesions in the brainstem, cerebellar, subcortical and cortical brain regions. There are varying clinical presentations of progressive supranuclear palsy with different neuroimaging signatures, presumed to be due to different topographical distributions and burden of tau. The classic Richardson syndrome presentation is considered a subcortical variant, whilst progressive supranuclear palsy with predominant speech and language impairment is considered a cortical variant, although the pathological underpinnings of these variants are unclear. In this case-control study, we aimed to determine whether patterns of regional tau pathology differed between these variants and whether tau burden correlated with neuroimaging. Thirty-three neuropathologically confirmed progressive supranuclear palsy patients with either the Richardson syndrome (
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