Evidence map›Paper›PMID 38660603›Full record

ArticleACS catalysis2024

Ultrahigh Throughput Evolution of Tryptophan Synthase in Droplets via an Aptamer Sensor.

Remkes A Scheele, Yanik Weber, Friederike E H Nintzel, Michael Herger, Tomasz S Kaminski, Florian Hollfelder

Open access · hybridAbstract read
In one paragraph

Article in ACS catalysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Remkes A ScheeleDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.ORCID https://orcid.org/0000-0002-5354-8286
Yanik WeberDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.
Friederike E H NintzelDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.ORCID https://orcid.org/0000-0002-0637-4383
Michael HergerDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.
Tomasz S KaminskiDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.ORCID https://orcid.org/0000-0001-5124-4548
Florian HollfelderDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.ORCID https://orcid.org/0000-0002-1367-6312
University of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tryptophan synthase catalyzes the synthesis of a wide array of noncanonical amino acids and is an attractive target for directed evolution. Droplet microfluidics offers an ultrahigh throughput approach to directed evolution (up to 10

Identifiers

PMID38660603
PMCPMC11036396
OpenAlexW4394681636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.