Evidence map›Paper›PMID 38660517›Full record

ArticleFrontiers in endocrinology2024

Associations between sex hormones, receptors, binding proteins and inflammatory bowel disease: a Mendelian randomization study.

Fei Zou, Yaxian Hu, Mengmeng Xu, Su Wang, Zengrong Wu, Feihong Deng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fei Zou *Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yaxian Hu *Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Mengmeng XuDepartment of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Su WangDepartment of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zengrong WuDepartment of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Feihong DengDepartment of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Gender differences existed in inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). Observational studies have revealed associations between sex hormones and IBD, such as estrogen and testosterone. However, the exact relationship between these sex hormones and IBD is unclear. Method: Based on the genome-wide association studies data of eight sex hormones, two sex hormone receptors, sex hormone-binding globulin (SHBG), total IBD and its two subtypes, we performed a two-sample Mendelian randomization (MR) study to analyze their mutual relationship. For estradiol (E2), progesterone (PROG), bioavailable testosterone (BAT), total testosterone (TT) and SHBG, sex-stratified MR analyses were also performed. Inverse variance weighted method, MR-Egger regression and Weighted median method were used for causal analyses. Sensitivity analyses were conducted to test the stability of causal relationships. Besides, a reverse MR analysis was performed to estimate the reverse causation. Results: E2 ( Conclusion: Findings of this study revealed the mutual causal associations between sex hormones and the risk of developing IBD.

Indexed as

Genome-Wide Association StudyGonadal Steroid HormonesInflammatory Bowel DiseasesMendelian Randomization AnalysisSex Hormone-Binding GlobulinColitis, UlcerativeCrohn DiseaseEstradiolFemaleHumansMalePolymorphism, Single NucleotideProgesteroneReceptors, EstrogenTestosteroneEstradiolGonadal Steroid HormonesProgesteroneReceptors, EstrogenSex Hormone-Binding GlobulinSHBG protein, humanTestosteroneestradiolinflammatory bowel diseaseMendelian randomizationprogesteronesex hormonetestosterone

Identifiers

PMID38660517
PMCPMC11039946
OpenAlexW4394681275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.