Evidence map›Paper›PMID 38660401›Full record

ArticleiScience2024

Effects of long-term closed and socially isolating spaceflight analog environment on default mode network connectivity as indicated by fMRI.

Yunxia Shen, Limin Peng, Hailong Chen, Pengfei Xu, Ke Lv, Zi Xu, Hui Shen, Guohua Ji, Jianghui Xiong, Dewen Hu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Yunxia ShenDepartment of Medical Imaging, Longgang Central Hospital of Shenzhen, Shenzhen, Guangdong 518116, China.
Limin PengCollege of Intelligence Science and Technology, National University of Defense Technology, Changsha, Hunan 410073, China.
Hailong ChenState Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, Beijing 100094, China.
Pengfei XuShenzhen Key Laboratory of Affective and Social Neuroscience, Shenzhen University, Shenzhen, Guangdong 518060, China.
Ke LvState Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, Beijing 100094, China.
Zi XuDepartment of Health Technology Research and Development, Space Institute of Southern China, Shenzhen, Guangdong 518117, China.
Hui ShenCollege of Intelligence Science and Technology, National University of Defense Technology, Changsha, Hunan 410073, China.
Guohua JiState Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, Beijing 100094, China.
Jianghui XiongState Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, Beijing 100094, China.
Dewen HuCollege of Intelligence Science and Technology, National University of Defense Technology, Changsha, Hunan 410073, China.
Yinghui LiState Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, Beijing 100094, China.
Mingwu LouDepartment of Medical Imaging, Longgang Central Hospital of Shenzhen, Shenzhen, Guangdong 518116, China.
Ling-Li ZengCollege of Intelligence Science and Technology, National University of Defense Technology, Changsha, Hunan 410073, China.
Lina QuState Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, Beijing 100094, China.
National University of Defense Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-term manned spaceflight and extraterrestrial planet settlement become the focus of space powers. However, the potential influence of closed and socially isolating spaceflight on the brain function remains unclear. A 180-day controlled ecological life support system integrated experiment was conducted, establishing a spaceflight analog environment to explore the effect of long-term socially isolating living. Three crewmembers were enrolled and underwent resting-state fMRI scanning before and after the experiment. We performed both seed-based and network-based analyses to investigate the functional connectivity (FC) changes of the default mode network (DMN), considering its key role in multiple higher-order cognitive functions. Compared with normal controls, the leader of crewmembers exhibited significantly reduced within-DMN and between-DMN FC after the experiment, while two others exhibited opposite trends. Moreover, individual differences of FC changes were further supported by evidence from behavioral analyses. The findings may shed new light on the development of psychological protection for space exploration.

Indexed as

Cognitive neuroscienceHealth sciencesSpace sciences

Identifiers

PMID38660401
PMCPMC11039341
OpenAlexW4393281923

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.