Evidence map›Paper›PMID 38660114›Full record

ArticleInnovation in aging2024

Associations Between Depression Symptom Burden and Delirium Risk: A Prospective Cohort Study.

Arlen Gaba, Peng Li, Xi Zheng, Chenlu Gao, Ruixue Cai, Kun Hu, Lei Gao

Open access · goldAbstract read
In one paragraph

Article in Innovation in aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Arlen GabaMedical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Peng LiMedical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-4684-4909
Xi ZhengMedical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Chenlu GaoMedical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Ruixue CaiMedical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Kun HuMedical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Lei GaoMedical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-1476-1460
Brigham and Women's Hospital · US

Funding

Circadian Multiscale Activity Regulation and the Risk for Delirium in Elderly Hospitalized PatientsR03AG067985 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GAO, LEI · 2020 to 2021
$268k
NIA NIH HHS R03 AG067985
6 · The paper itself

Abstract

Background and Objectives: Delirium and depression are prevalent in aging. There is considerable clinical overlap, including shared symptoms and comorbid conditions, including Alzheimer's disease, functional decline, and mortality. Despite this, the long-term relationship between depression and delirium remains unclear. This study assessed the associations of depression symptom burden and its trajectory with delirium risk in a 12-year prospective study of older hospitalized individuals. Research Design and Methods: A total of 319 141 UK Biobank participants between 2006 and 2010 (mean age 58 years [range 37-74, Results: A total of 5 753 (15 per 1 000) newly developed delirium during follow-up. Increased risk for delirium was seen for mild (aggregated scores 1-2, hazards ratio, HR = 1.16, [95% confidence interval (CI): 1.08-1.25], Discussion and Implications: Depression symptom burden and worsening trajectory predicted delirium risk during hospitalization. Increased awareness of subclinical depression symptoms may aid delirium prevention.

Indexed as

Altered mental statusAlzheimer’s diseaseAnxietyDementiaPostoperative

Identifiers

PMID38660114
PMCPMC11041407
OpenAlexW4392762807

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.