ArticleWorld journal of clinical cases2024
Identification of marker genes associated with N6-methyladenosine and autophagy in ulcerative colitis.
Article in World journal of clinical cases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBoth N6-methyladenosine (m6A) methylation and autophagy are considered relevant to the pathogenesis of ulcerative colitis (UC). However, a systematic exploration of the role of the com-bination of m6A methylation and autophagy in UC remains to be performed.
aimTo elucidate the autophagy-related genes of m6A with a diagnostic value for UC.
methodsThe correlation between m6A-related genes and autophagy-related genes (ARGs) was analyzed. Finally, gene set enrichment analysis (GSEA) was performed on the characteristic genes. Additionally, the expression levels of four characteristic genes were verified in dextran sulfate sodium (DSS)-induced colitis in mice.
resultsGSEA indicated that BAG3, P4HB and TP53INP2 were involved in the inflammatory response and TNF-α signalling
conclusionThis study identified four m6A-ARGs that predict the occurrence of UC, thus providing a scientific reference for further studies on the pathogenesis of UC.
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