Evidence map›Paper›PMID 38660006›Full record

ArticleHealth science reports2024

Current approaches in smart nano-inspired drug delivery: A narrative review.

Sri Harsha Boppana, L V Simhachalam Kutikuppala, Sushil Sharma, Madhavrao C, Gaurav Rangari, Arup Kumar Misra, Venkataramana Kandi, Snehasish Mishra, Puneet Kumar Singh, Ali A Rabaan and 2 more

Abstract read
In one paragraph

Article in Health science reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sri Harsha BoppanaDepartment of Anesthesia and Critical Care Johns Hopkins School of Medicine Baltimore Maryland USA.
L V Simhachalam KutikuppalaDepartment of Pharmacology All India Institute of Medical Sciences (AIIMS) Mangalagiri Andhra Pradesh India.
Sushil SharmaDepartment of Pharmacology All India Institute of Medical Sciences (AIIMS) Mangalagiri Andhra Pradesh India.
Madhavrao CDepartment of Pharmacology All India Institute of Medical Sciences (AIIMS) Mangalagiri Andhra Pradesh India.
Gaurav RangariDepartment of Pharmacology All India Institute of Medical Sciences (AIIMS) Mangalagiri Andhra Pradesh India.
Arup Kumar MisraDepartment of Pharmacology All India Institute of Medical Sciences (AIIMS) Mangalagiri Andhra Pradesh India.
Venkataramana KandiDepartment of Microbiology Prathima Institute of Medical Sciences Karimnagar Telangana India.ORCID 0000-0002-7197-0448
Snehasish MishraSchool of Biotechnology, Campus-11 KIIT Deemed-to-be-University Bhubaneswar Odisha India.ORCID 0000-0002-3896-5831
Puneet Kumar SinghSchool of Biotechnology, Campus-11 KIIT Deemed-to-be-University Bhubaneswar Odisha India.
Ali A RabaanMolecular Diagnostic Laboratory Johns Hopkins Aramco Healthcare Dhahran Saudi Arabia.
Ranjan K MohapatraDepartment of Chemistry Government College of Engineering Keonjhar Odisha India.ORCID 0000-0001-7623-3343
Md Kudrat-E-ZahanDepartment of Chemistry Rajshahi University Rajshahi Bangladesh.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: The traditional drug delivery approach involves systemic administration of a drug that could be nonspecific in targeting, low on efficacy, and with severe side-effects. To address such challenges, the field of smart drug delivery has emerged aiming at designing and developing delivery systems that can target specific cells, tissues, and organs and have minimal off-target side-effects. Methods: A literature search was done to collate papers and reports about the currently available various strategies for smart nano-inspired drug delivery. The databases searched were PubMed, Scopus, and Google Scholar. Based on selection criteria, the most pertinent and recent items were included. Results: Smart drug delivery is a cutting-edge revolutionary intervention in modern medicines to ensure effective and safe administration of therapeutics to target sites. These hold great promise for targeted and controlled delivery of therapeutic agents to improve the efficacy with reduced side-effects as compared to the conventional drug delivery approaches. Current smart drug delivery approaches include nanoparticles, liposomes, micelles, and hydrogels, each with its own advantages and limitations. The success of these delivery systems lies in engineering and designing them, and optimizing their pharmacokinetics and pharmacodynamics properties. Conclusion: Development of drug delivery systems that can get beyond various physiological and clinical barriers, as observed in conventionally administered chemotherapeutics, has been possible through recent advancements. Using multifunctional targeting methodologies, smart drug delivery tries to localize therapy to the target location, reduces cytotoxicity, and improves the therapeutic index. Rapid advancements in research and development in smart drug delivery provide wider and more promising avenues to guarantee a better healthcare system, improve patient outcomes, and achieve higher levels of effective medical interventions like personalized medicine.

Indexed as

hydrogelsliposomesmicellesnanoparticlessmart drug deliverytherapeutics

Identifiers

PMID38660006
PMCPMC11040566

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.