Evidence map›Paper›PMID 38659956›Full record

ArticlebioRxiv : the preprint server for biology2024

Loss of developmentally derived Irf8+ macrophages promotes hyperinnervation and arrhythmia in the adult zebrafish heart.

Shannon E Paquette, Cliff I Oduor, Amy Gaulke, Sabina Stefan, Peter Bronk, Vanny Dafonseca, Nikolai Barulin, Cadence Lee, Rachel Carley, Alan R Morrison and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Shannon E PaquetteDepartment of Pathology & Laboratory Medicine, Brown University, Providence, RI, 02912, USA.ORCID 0000-0002-7659-0612
Cliff I OduorDepartment of Pathology & Laboratory Medicine, Brown University, Providence, RI, 02912, USA.
Amy GaulkeDepartment of Pathology & Laboratory Medicine, Brown University, Providence, RI, 02912, USA.
Sabina StefanDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Peter BronkCardiovascular Research Center, Brown University Warren Alpert Medical School, Providence, RI, 02912, USA.
Vanny DafonsecaDepartment of Pathology & Laboratory Medicine, Brown University, Providence, RI, 02912, USA.
Nikolai BarulinDepartment of Pathology & Laboratory Medicine, Brown University, Providence, RI, 02912, USA.
Cadence LeeVascular Research Laboratory, Providence VA Medical Center, Providence, RI, 02908, USA.
Rachel CarleyVascular Research Laboratory, Providence VA Medical Center, Providence, RI, 02908, USA.
Alan R MorrisonVascular Research Laboratory, Providence VA Medical Center, Providence, RI, 02908, USA.
Bum-Rak ChoiCardiovascular Research Center, Brown University Warren Alpert Medical School, Providence, RI, 02912, USA.
Jeffrey A BaileyDepartment of Pathology & Laboratory Medicine, Brown University, Providence, RI, 02912, USA.
Jessica S PlavickiDepartment of Pathology & Laboratory Medicine, Brown University, Providence, RI, 02912, USA.ORCID 0000-0002-7619-9234
John Brown University · USOcean Institute · USBrown University · USDana-Farber Cancer Institute · USDartmouth College · US

Funding

Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI ROUNDS, SHARON IRENE SMITH · 2013 to 2022
$21.3M
Combining Targeted Demethylation with Noncoding RNA-mediated mRNA Stabilization as a Strategy for Therapeutic Arteriogenesis in the AgedR01HL163005 · NHLBI · OCEAN STATE RESEARCH INSTITUTE, INC. · PI MORRISON, ALAN ROSS · 2022 to 2025
$2.3M
Development of Rac-Targeted Therapeutic Strategy for Treatment of Calcific AtherosclerosisR01HL139795 · NHLBI · OCEAN STATE RESEARCH INSTITUTE, INC. · PI MORRISON, ALAN ROSS · 2018 to 2022
$1.8M
Determining the role of macrophages in the developing cardiac conduction systemF31HL156460 · NHLBI · BROWN UNIVERSITY · PI PAQUETTE, SHANNON ELIZABETH · 2021 to 2023
$131k
Calcific Atherosclerosis is Mediated by Macrophage Adhesion SignalingIK2BX002527 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI MORRISON, ALAN ROSS · 2015 to 2017
–
BLRD VA IK2 BX002527NHLBI NIH HHS F31 HL156460NHLBI NIH HHS R01 HL139795NHLBI NIH HHS R01 HL163005NIGMS NIH HHS P20 GM103652
6 · The paper itself

Abstract

Recent developments in cardiac macrophage biology have broadened our understanding of the critical functions of macrophages in the heart. As a result, there is further interest in understanding the independent contributions of distinct subsets of macrophage to cardiac development and function. Here, we demonstrate that genetic loss of interferon regulatory factor 8 (Irf8)-positive embryonic-derived macrophages significantly disrupts cardiac conduction, chamber function, and innervation in adult zebrafish. At 4 months post-fertilization (mpf), homozygous

Indexed as

arrhythmiadevelopmentepicardialepicardiumheartirf8macrophagesingle cell transcriptomicsUp to 10zebrafish

Identifiers

PMID38659956
PMCPMC11042273
OpenAlexW4394989129

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.