Evidence map›Paper›PMID 38659853›Full record

ArticlebioRxiv : the preprint server for biology2024

Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties.

Jae Hun Shin, Jooyoung Park, Jaechul Lim, Jaekwang Jeong, Ravi K Dinesh, Stephen E Maher, Jeonghyun Kim, Soyeon Park, Jun Young Hong, John Wysolmerski and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Jae Hun ShinIntegrative Science and Engineering Division, Underwood International College, Yonsei University, Incheon 21983, Korea.ORCID 0000-0001-6066-0017
Jooyoung ParkDepartment of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Korea.
Jaechul LimCollege of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
Jaekwang JeongInternal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, U.S.
Ravi K DineshDepartment of Pathology, Stanford University, Stanford, California 94305, U.S.
Stephen E MaherDepartment of Urology, Yale University School of Medicine, New Haven, Connecticut 06520, U.S.
Jeonghyun KimInstitute of Advanced Bio-Industry Convergence, Yonsei University, Seoul, Korea.
Soyeon ParkInstitute of Advanced Bio-Industry Convergence, Yonsei University, Seoul, Korea.
Jun Young HongDepartment of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
John WysolmerskiInternal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, U.S.
Jungmin ChoiDepartment of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Korea.ORCID 0000-0002-8614-0973
Alfred L M BothwellDept. of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, 505 S. 45 Street., Omaha, NE 68198, U.S.
Yale University · USYonsei University · KRKorea University · KRSeoul National University · KRStanford University · US

Funding

PMCA2 regulates mammary gland involution and breast cancerR01HD076248 · NICHD · YALE UNIVERSITY · PI WYSOLMERSKI, JOHN J · 2014 to 2024
$4.4M
Regulatory T Cell Control of Intestinal TumorigenesisR01CA168670 · NCI · YALE UNIVERSITY · PI BOTHWELL, ALFRED LM · 2014 to 2018
$2.1M
Heterodimerization of the Calcium-sensing receptor with the GabaB receptors in the breast.R01HD100468 · NICHD · YALE UNIVERSITY · PI WYSOLMERSKI, JOHN J · 2020 to 2024
$2.1M
NCI NIH HHS R01 CA168670NICHD NIH HHS R01 HD076248NICHD NIH HHS R01 HD100468
6 · The paper itself

Abstract

Metastasis is the leading cause of cancer-related mortality. Paneth cells provide stem cell niche factors in homeostatic conditions, but the underlying mechanisms of cancer stem cell niche development are unclear. Here we report that Dickkopf-2 (DKK2) is essential for the generation of cancer cells with Paneth cell properties during colon cancer metastasis. Splenic injection of

Indexed as

Colon cancerDKK2MetastasisPaneth cell properties

Identifiers

PMID38659853
PMCPMC11042192
OpenAlexW4394800510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.