Evidence map›Paper›PMID 38659843›Full record

ArticlebioRxiv : the preprint server for biology2024

Enhancing Prosthetic Vision by Upgrade of a Subretinal Photovoltaic Implant in situ.

Mohajeet B Bhuckory, Nicharee Monkongpitukkul, Andrew Shin, Anna Kochnev Goldstein, Nathan Jensen, Sarthak V Shah, Davis Pham-Howard, Emma Butt, Roopa Dalal, Ludwig Galambos and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Mohajeet B BhuckoryHansen Experimental Physics Laboratory, Stanford University, Stanford, CA 94303, USA.ORCID 0000-0002-2824-1899
Nicharee MonkongpitukkulDepartment of Ophthalmology, Stanford University, Stanford, CA, USA.
Andrew ShinDepartment of Material Science, Stanford University, Stanford, CA, USA.
Anna Kochnev GoldsteinDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.
Nathan JensenDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.
Sarthak V ShahDepartment of Ophthalmology, Stanford University, Stanford, CA, USA.
Davis Pham-HowardHansen Experimental Physics Laboratory, Stanford University, Stanford, CA 94303, USA.
Emma ButtDepartment of Physics, University of Strathclyde, Glasgow, Scotland, UK.
Roopa DalalDepartment of Ophthalmology, Stanford University, Stanford, CA, USA.
Ludwig GalambosHansen Experimental Physics Laboratory, Stanford University, Stanford, CA 94303, USA.
Keith MathiesonDepartment of Physics, University of Strathclyde, Glasgow, Scotland, UK.
Theodore KaminsDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.
Daniel PalankerHansen Experimental Physics Laboratory, Stanford University, Stanford, CA 94303, USA.
Stanford University · USUniversity of Strathclyde · GBPrince of Songkla University · TH

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Electronic photoreceptors for restoration of sight in retinal degenerationR01EY035227 · NEI · STANFORD UNIVERSITY · PI DANIEL V PALANKER · 2023 to 2026
$2.7M
NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY035227
6 · The paper itself

Abstract

In patients with atrophic age-related macular degeneration, subretinal photovoltaic implant (PRIMA) provided visual acuity up to 20/440, matching its 100μm pixels size. Next-generation implants with smaller pixels should significantly improve the acuity. This study in rats evaluates removal of a subretinal implant, replacement with a newer device, and the resulting grating acuity in-vivo. Six weeks after the initial implantation with planar and 3-dimensional devices, the retina was re-detached, and the devices were successfully removed. Histology demonstrated a preserved inner nuclear layer. Re-implantation of new devices into the same location demonstrated retinal re-attachment to a new implant. New devices with 22μm pixels increased the grating acuity from the 100μm capability of PRIMA implants to 28μm, reaching the limit of natural resolution in rats. Reimplanted devices exhibited the same stimulation threshold as for the first implantation of the same implants in a control group. This study demonstrates the feasibility of safely upgrading the subretinal photovoltaic implants to improve prosthetic visual acuity.

Indexed as

Age-related macular degenerationexplantation surgeryneuronal migrationphotoreceptor deathRetinal Prosthesisvision restoration

Identifiers

PMID38659843
PMCPMC11042236
OpenAlexW4394963987

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.