Evidence map›Paper›PMID 38659837›Full record

ArticlebioRxiv : the preprint server for biology2024

Engineering, structure, and immunogenicity of a Crimean-Congo hemorrhagic fever virus pre-fusion heterotrimeric glycoprotein complex.

Elizabeth McFadden, Stephanie R Monticelli, Albert Wang, Ajit R Ramamohan, Thomas G Batchelor, Ana I Kuehne, Russell R Bakken, Alexandra L Tse, Kartik Chandran, Andrew S Herbert and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Elizabeth McFaddenDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA.
Stephanie R MonticelliUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Albert WangDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Ajit R RamamohanDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA.
Thomas G BatchelorUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Ana I KuehneUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Russell R BakkenUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Alexandra L TseDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Kartik ChandranDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Andrew S HerbertUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Jason S McLellanDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA.
United States Army Medical Research Institute of Infectious Diseases · USAlbert Einstein College of Medicine · USThe University of Texas at Austin · USOak Ridge Associated Universities · US

Funding

Medical Scientist Training ProgramT32GM149364 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Myles H. Akabas · 2023 to 2026
$7.5M
Structure-based Vaccine Design for CCHFVR01AI152246 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI CHANDRAN, KARTIK, MCLELLAN, JASON SCOTT · 2020 to 2024
$2.2M
An Eiger2 XE 9M detector for the NYSBC-operated NYX beamline at NSLS-IIS10OD030394 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI BATTAILE, KEVIN P · 2021 to 2021
$1.8M
NIAID NIH HHS R01 AI152246NIGMS NIH HHS T32 GM149364NIH HHS S10 OD030394
6 · The paper itself

Abstract

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus that can cause severe disease in humans with case fatality rates of 10-40%. Although structures of CCHFV glycoproteins GP38 and Gc have provided insights into viral entry and defined epitopes of neutralizing and protective antibodies, the structure of glycoprotein Gn and its interactions with GP38 and Gc have remained elusive. Here, we used structure-guided protein engineering to produce a stabilized GP38-Gn-Gc heterotrimeric glycoprotein complex (GP38-Gn

Identifiers

PMID38659837
PMCPMC11042304
OpenAlexW4395008775

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.