Evidence map›Paper›PMID 38659764›Full record

ArticlebioRxiv : the preprint server for biology2024

The response to single-gene duplication implicates translation as a key vulnerability in aneuploid yeast.

H Auguste Dutcher, James Hose, Hollis Howe, Julie Rojas, Audrey P Gasch

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

H Auguste DutcherORCID 0000-0003-2013-4391
James Hose
Hollis Howe
Julie RojasORCID 0000-0001-8714-1532
Audrey P GaschORCID 0000-0002-8182-257X
University of Wisconsin–Madison · US

Funding

Institutional Training in the Genomic SciencesT32HG002760 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI Qiongshi Lu · 2003 to 2026
$17.7M
Molecular approaches to sensitizing eukaryotic cells to aneuploidyR01CA229532 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI GASCH, AUDREY · 2018 to 2022
$1.8M
Understanding how aneuploidy disrupts quiescence in the model eukaryote Saccharomyces cerevisiaeR01GM148975 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Audrey Gasch · 2023 to 2026
$1.2M
NCI NIH HHS R01 CA229532NHGRI NIH HHS T32 HG002760NIGMS NIH HHS R01 GM148975
6 · The paper itself

Abstract

Aneuploidy produces myriad consequences in health and disease, yet models of the deleterious effects of chromosome amplification are still widely debated. To distinguish the molecular determinants of aneuploidy stress, we measured the effects of duplicating individual genes in cells with varying chromosome duplications, in wild-type cells and cells sensitized to aneuploidy by deletion of RNA-binding protein Ssd1. We identified gene duplications that are nearly neutral in wild-type euploid cells but significantly deleterious in euploids lacking

Identifiers

PMID38659764
PMCPMC11042342
OpenAlexW4394988132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.