Evidence map›Paper›PMID 38659761›Full record

ArticlebioRxiv : the preprint server for biology2024

Cytosolic Ribosomal Protein Haploinsufficiency affects Mitochondrial Morphology and Respiration.

Agustian Surya, Blythe Marie Bolton, Reed Rothe, Raquel Mejia-Trujillo, Qiuxia Zhao, Amanda Leonita, Yue Liu, Rekha Rangan, Yasash Gorusu, Pamela Nguyen and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Agustian SuryaDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Blythe Marie BoltonDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Reed RotheDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Raquel Mejia-TrujilloDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Qiuxia ZhaoDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Amanda LeonitaDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Yue LiuDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Rekha RanganDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Yasash GorusuDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Pamela NguyenDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Can CenikDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
Elif Sarinay CenikDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0001-8514-5505
The University of Texas at Austin · US

Funding

Role of Nucleolus and Ribosomes in Organismal Growth and HomeostasisR35GM138340 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Elif Sarinay Cenik · 2020 to 2026
$2.4M
NIGMS NIH HHS R35 GM138340
6 · The paper itself

Abstract

The interplay between ribosomal protein composition and mitochondrial function is essential for sustaining energy homeostasis. Precise stoichiometric production of ribosomal proteins is crucial to maximize protein synthesis efficiency while reducing the energy costs to the cell. However, the impact of this balance on mitochondrial ATP generation, morphology and function remains unclear. Particularly, the loss of a single copy ribosomal protein gene is observed in Mendelian disorders like Diamond Blackfan Anemia and is common in somatic tumors, yet the implications of this imbalance on mitochondrial function and energy dynamics are still unclear. In this study, we investigated the impact of haploinsufficiency for four ribosomal protein genes implicated in ribosomopathy disorders (

Identifiers

PMID38659761
PMCPMC11042305
OpenAlexW4394989233

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.