Evidence map›Paper›PMID 38659749›Full record

ArticlebioRxiv : the preprint server for biology2025

Mesolimbic dopamine ramps reflect environmental timescales.

Joseph R Floeder, Huijeong Jeong, Ali Mohebi, Vijay Mohan K Namboodiri

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Joseph R FloederNeuroscience Graduate Program, University of California, San Francisco, CA, USA.
Huijeong JeongDepartment of Neurology, University of California, San Francisco, CA, USA.
Ali MohebiDepartment of Neurology, University of California, San Francisco, CA, USA.ORCID 0000-0001-7291-3448
Vijay Mohan K NamboodiriNeuroscience Graduate Program, University of California, San Francisco, CA, USA.ORCID 0000-0002-6674-610X

Funding

Predoctoral Training in NeurobiologyT32NS115706 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAMUEL JEREMY PLEASURE · 2020 to 2026
$3.4M
Prospective and retrospective learning in orbitofrontal cortexR01MH129582 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Vijay Mohan K Namboodiri · 2022 to 2026
$2.2M
Neural encoding of associative learning by orbitofrontal cortex circuitsR00MH118422 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI K NAMBOODIRI, VIJAY MOHAN · 2020 to 2022
$747k
Neural encoding of associative learning by orbitofrontal cortex circuitsK99MH118422 · NIMH · UNIVERSITY OF WASHINGTON · PI K NAMBOODIRI, VIJAY MOHAN · 2019 to 2020
$141k
NIMH NIH HHS R00 MH118422NIMH NIH HHS R01 MH129582NINDS NIH HHS T32 NS115706
6 · The paper itself

Abstract

Mesolimbic dopamine activity occasionally exhibits ramping dynamics, reigniting debate on theories of dopamine signaling. This debate is ongoing partly because the experimental conditions under which dopamine ramps emerge remain poorly understood. Here, we show that during Pavlovian and instrumental conditioning, mesolimbic dopamine ramps are only observed when the inter-trial interval is short relative to the trial period. These results constrain theories of dopamine signaling and identify a critical variable determining the emergence of dopamine ramps.

Identifiers

PMID38659749
PMCPMC11042231

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.