Evidence map›Paper›PMID 38659743›Full record

ArticlebioRxiv : the preprint server for biology2024

Bridging the Gap: Multi-Omics Profiling of Brain Tissue in Alzheimer's Disease and Older Controls in Multi-Ethnic Populations.

Joseph S Reddy, Laura Heath, Abby Vander Linden, Mariet Allen, Katia de Paiva Lopes, Fatemeh Seifar, Erming Wang, Yiyi Ma, William L Poehlman, Zachary S Quicksall and 43 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

53 authors at 11 institutions in 1 country.

Joseph S ReddyMayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224.ORCID 0000-0002-1783-4453
Laura HeathSage Bionetworks, 2901 3rd Ave #330, Seattle, WA 98121.
Abby Vander LindenSage Bionetworks, 2901 3rd Ave #330, Seattle, WA 98121.
Mariet AllenMayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224.
Katia de Paiva LopesRush Alzheimer's Disease Center, Rush University Medical Center, 1750 W Harrison St, Chicago, IL 60612.
Fatemeh SeifarEmory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322.
Erming WangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1428 Madison Ave, New York, NY 10029.
Yiyi MaColumbia University Irving Medical Center, 622 W 168th St, New York, NY 10032.
William L PoehlmanSage Bionetworks, 2901 3rd Ave #330, Seattle, WA 98121.
Zachary S QuicksallMayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224.
Alexi RunnelsNew York Genome Center, 101 6th Ave, New York, NY 10013.
Yanling WangRush Alzheimer's Disease Center, Rush University Medical Center, 1750 W Harrison St, Chicago, IL 60612.
Duc M DuongEmory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322.
Luming YinEmory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322.
Kaiming XuEmory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322.
Erica S ModesteEmory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322.
Anantharaman ShantaramanEmory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322.
Eric B DammerEmory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322.
Lingyan PingEmory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322.
Stephanie R OatmanMayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224.
Jo ScanlanSage Bionetworks, 2901 3rd Ave #330, Seattle, WA 98121.
Charlotte HoMayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224.
Minerva M CarrasquilloMayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224.
Merve AtikMayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224.
Geovanna YepezMayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224.
Adriana O MitchellMayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224.
Thuy T NguyenMayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224.
Xianfeng ChenMayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224.
David X MarquezRush Alzheimer's Disease Center, Rush University Medical Center, 1750 W Harrison St, Chicago, IL 60612.
Hasini ReddyColumbia University Irving Medical Center, 622 W 168th St, New York, NY 10032.
Harrison XiaoColumbia University Irving Medical Center, 622 W 168th St, New York, NY 10032.
Sudha SeshadriThe Glen Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas, 8300 Floyd Curl Drive, San Antonio TX 78229.
Richard MayeuxColumbia University Irving Medical Center, 622 W 168th St, New York, NY 10032.
Stefan ProkopUniversity of Florida, Gainesville, FL 32611.
Edward B LeeCenter for Neurodegenerative Disease Brain Bank at the University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104-2676.
Geidy E SerranoBanner Sun Health Research Institute, 10515 W Santa Fe Dr, Sun City, AZ 85351.
Thomas G BeachBanner Sun Health Research Institute, 10515 W Santa Fe Dr, Sun City, AZ 85351.
Andrew F TeichColumbia University Irving Medical Center, 622 W 168th St, New York, NY 10032.
Varham HaroutunianDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1428 Madison Ave, New York, NY 10029.
Edward J FoxEmory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322.
Marla GearingEmory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322.
Aliza WingoEmory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322.
Thomas WingoEmory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322.
James J LahEmory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322.
Allan I LeveyEmory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322.
Dennis W DicksonMayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224.
Lisa L BarnesRush Alzheimer's Disease Center, Rush University Medical Center, 1750 W Harrison St, Chicago, IL 60612.
Philip De JagerColumbia University Irving Medical Center, 622 W 168th St, New York, NY 10032.
Bin ZhangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1428 Madison Ave, New York, NY 10029.
David BennettRush Alzheimer's Disease Center, Rush University Medical Center, 1750 W Harrison St, Chicago, IL 60612.
Nicholas T SeyfriedEmory University School of Medicine, 1440 Clifton Rd, Atlanta, GA 30322.
Anna K GreenwoodSage Bionetworks, 2901 3rd Ave #330, Seattle, WA 98121.
Nilüfer Ertekin-TanerMayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224.
Emory University · USMayo Clinic in Florida · USColumbia University Irving Medical Center · USRush University Medical Center · USSage Bionetworks · USIcahn School of Medicine at Mount Sinai · USBanner Sun Health Research Institute · USInstitute for Neurodegenerative Disorders · USNew York Genome Center · USUniversity of Florida · USUniversity of Pennsylvania · US

Funding

Vascular Structure and Function in Cognitive AgingP01AG003949 · NIA · YESHIVA UNIVERSITY · PI Richard B. LIPTON · 1985 to 2026
$73.9M
SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
Peripheral and Central Biomarkers of Alzheimer's Disease in Diverse CohortsU19AG074879 · NIA · MAYO CLINIC JACKSONVILLE · PI Minerva Maria Carrasquillo, NILUFER ERTEKIN-TANER · 2023 to 2026
$42.0M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5M
The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI ALLAN I LEVEY · 2020 to 2026
$29.0M
UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI ALIREZA ATRI · 2021 to 2026
$24.9M
Research Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVID A WOLK · 2021 to 2026
$24.8M
Integrating the exposome and methylome to inform brain molecular changes in ADRD across established diverse cohorts.U01AG046139 · NIA · UNIVERSITY OF FLORIDA · PI ERTEKIN-TANER, NILUFER, FUNK, CORY · 2013 to 2022
$24.6M
Understanding Environmental Contributions to Heterogeneity in bvFTD.P01AG066597 · NIA · UNIVERSITY OF PENNSYLVANIA · PI David John Irwin, Corey T McMillan · 2020 to 2026
$18.8M
Project IV "Tackling Heterogeneity of Cognitive Trajectory in LBD"U19AG062418 · NIA · UNIVERSITY OF PENNSYLVANIA · PI CHEN-PLOTKIN, ALICE S · 2019 to 2023
$18.1M
NIA NIH HHS P01 AG003949NIA NIH HHS P01 AG017216NIA NIH HHS P01 AG066597NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG066511NIA NIH HHS P30 AG072972NIA NIH HHS P30 AG072979NIA NIH HHS P30 AG072980NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG025711NIA NIH HHS R01 AG018023NIA NIH HHS R01 AG032990NIA NIH HHS R01 AG061796NIA NIH HHS R01 AG072120NIA NIH HHS R01 AG075827NIA NIH HHS R01 AG079170NIA NIH HHS RF1 AG062181NIA NIH HHS U01 AG006786NIA NIH HHS U01 AG046139NIA NIH HHS U01 AG061357NIA NIH HHS U19 AG062418NIA NIH HHS U19 AG074879NINDS NIH HHS R01 NS080820NINDS NIH HHS U24 NS072026
6 · The paper itself

Abstract

introductionMulti-omics studies in Alzheimer's disease (AD) revealed many potential disease pathways and therapeutic targets. Despite their promise of precision medicine, these studies lacked African Americans (AA) and Latin Americans (LA), who are disproportionately affected by AD.

methodsTo bridge this gap, Accelerating Medicines Partnership in AD (AMP-AD) expanded brain multi-omics profiling to multi-ethnic donors.

resultsWe generated multi-omics data and curated and harmonized phenotypic data from AA (n=306), LA (n=326), or AA DISCUSSION: Inclusion of traditionally underrepresented groups in multi-omics studies is essential to discover the full spectrum of precision medicine targets that will be pertinent to all populations affected with AD.

Indexed as

Alzheimer’s diseasedata descriptormulti-omicsprecision medicineproteometranscriptomewhole genome sequencing

Identifiers

PMID38659743
PMCPMC11042309
OpenAlexW4394988074

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.