Evidence map›Paper›PMID 38659738›Full record

ArticleResearch square2024

Forskolin reverses the O-GlcNAcylation dependent decrease in GABAAR current amplitude at hippocampal synapses possibly at a neurosteroid site on GABAARs.

Shekinah Phillips, John C Chatham, Lori L McMahon

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Shekinah PhillipsUniversity of Alabama at Birmingham.
John C ChathamUniversity of Alabama at Birmingham.
Lori L McMahonMedical University of South Carolina.
University of Alabama at Birmingham · USMedical University of South Carolina · US

Funding

Consequences of Noradrenergic Degeneration in the Novel TgF344-AD Rat ModelR01AG066489 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MCMAHON, LORI LYNN · 2020 to 2024
$2.9M
UAB Neuroscience Roadmap Scholars ProgramR25NS089463 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LUBIN, FARAH DOMINIQUE · 2014 to 2024
$2.7M
O-GlcNac Modulation of GABAergic TransmissionF99NS134163 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PHILLIPS, SHEKINAH · 2023 to 2024
$81k
NIA NIH HHS R01 AG066489NINDS NIH HHS F99 NS134163NINDS NIH HHS R25 NS089463
6 · The paper itself

Abstract

GABAergic transmission is influenced by post-translational modifications, like phosphorylation, impacting channel conductance, allosteric modulator sensitivity, and membrane trafficking. O-GlcNAcylation is a post-translational modification involving the O-linked attachment of β-N-acetylglucosamine on serine/threonine residues. Previously we reported an acute increase in O-GlcNAcylation elicits a long-term depression of evoked GABA

Identifiers

PMID38659738
PMCPMC11042418
OpenAlexW4394681673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.