Evidence map›Paper›PMID 38659572›Full record

ArticleFrontiers in pharmacology2024

Use of tetraethylammonium (TEA) and Tris loading for blocking TRPM7 channels in intact cells.

Katherine G Holderby, J Ashot Kozak

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Katherine G HolderbyUndergraduate Program in Physiology and Neuroscience, Dayton, OH, United States.
J Ashot KozakDepartment of Neuroscience, Cell Biology and Physiology, Boonshoft School of Medicine and College of Science and Mathematics, Wright State University, Dayton, OH, United States.
Division of Undergraduate Education · USWright State University · US

Funding

TRPM7 and Cellular pHR01AI114804 · NIAID · WRIGHT STATE UNIVERSITY · PI KOZAK, JULIUSZ ASHOT · 2015 to 2019
$1.8M
Sodium Influx Assay for Measurement of TRPM7 Channel Activity in Intact CellsR21AI144337 · NIAID · WRIGHT STATE UNIVERSITY · PI KOZAK, JULIUSZ ASHOT · 2020 to 2021
$409k
NIAID NIH HHS R01 AI114804NIAID NIH HHS R21 AI144337
6 · The paper itself

Abstract

Tetraethylammonium (TEA), a quaternary ammonium compound, is a well-known blocker of potassium channels belonging to various subfamilies, such as K

Indexed as

channel-kinaseHEK293Jurkat T celllymphocytemagnesiumtetraethylammonium iontetramethylammonium ionTris hydrochloride

Identifiers

PMID38659572
PMCPMC11039802
OpenAlexW4394687683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.