Evidence map›Paper›PMID 38659544›Full record

ArticleCureus2024

A Case of a Metastatic Pancreatic Neuroendocrine Tumor: A Surgical Conundrum Wrapped in Functionality's Embrace.

Adam Mylonakis, Michail Vailas, Panagiotis Sakarellos, Lysandros Karydakis, Eleandros Kyros, Spyridon Davakis, Alexandros Papalampros, Evaggelos Felekouras

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Adam MylonakisFirst Department of Surgery, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Michail VailasFirst Department of Surgery, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Panagiotis SakarellosFirst Department of Surgery, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Lysandros KarydakisFirst Department of Surgery, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Eleandros KyrosFirst Department of Surgery, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Spyridon DavakisFirst Department of Surgery, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Alexandros PapalamprosFirst Department of Surgery, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Evaggelos FelekourasFirst Department of Surgery, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Laiko General Hospital of Athens · GRNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case study reports a rare case of a non-functioning metastatic pancreatic neuroendocrine tumor (pNET) transforming into a functioning pNET. A 59-year-old male, previously treated with distal pancreatectomy, splenectomy, lymph node dissection, liver metastasectomy, and pharmacotherapy, presented with weakness, hypoglycemia, and daily episodes of watery diarrhea. A functioning neuroendocrine liver metastasis expressing insulin and gastrin was identified. Surgical intervention, including left lateral hepatectomy and microwave ablation of multiple intrahepatic lesions, resulted in symptom resolution and uneventful recovery. However, metastatic liver disease re-emerged seven months post-surgery, necessitating chemotherapy. This case highlights the importance of vigilance for symptom development in non-functioning pNETs, signaling potential disease relapse and phenotype transformation, and suggests surgical treatment as a viable option in select cases.

Indexed as

gastrinomaliver neoplasmneuroendocrine tumorpancreatic neoplasmsecondary insulinoma

Identifiers

PMID38659544
PMCPMC11042668
OpenAlexW4393150221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.