Evidence map›Paper›PMID 38659482›Full record

ArticleWorld journal of gastroenterology2024

Growth differentiation factor-15 serum concentrations reflect disease severity and anemia in patients with inflammatory bowel disease.

Ante Tonkic, Marko Kumric, Ivna Akrapovic Olic, Doris Rusic, Piero Marin Zivkovic, Daniela Supe Domic, Zeljko Sundov, Ivan Males, Josko Bozic

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ante TonkicBiology of Neoplasms, University of Split School of Medicine, Split 21000, Croatia.
Marko KumricDepartment of Pathophysiology, University of Split School of Medicine, Split 21000, Croatia.
Ivna Akrapovic OlicDepartment of Gastroenterology, University Hospital of Split, Split 21000, Croatia.
Doris RusicDepartment of Pharmacy, University of Split School of Medicine, Split 21000, Croatia.
Piero Marin ZivkovicDepartment of Gastroenterology, University Hospital of Split, Split 21000, Croatia.
Daniela Supe DomicDepartment of Medical Laboratory Diagnostics, University Hospital of Split, Split 21000, Croatia.
Zeljko SundovDepartment of Gastroenterology, University Hospital of Split, Split 21000, Croatia.
Ivan MalesDepartment of Surgery, University Hospital of Split, Split 21000, Croatia.
Josko BozicDepartment of Pathophysiology, University of Split School of Medicine, Split 21000, Croatia. josko.bozic@mefst.hr.
University of Split · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPopulation of patients with inflammatory bowel disease (IBD) is burdened by various extraintestinal manifestations which substantially contribute to greater morbidity and mortality. Growth-differentiation factor-15 (GDF-15) is often over-expressed under stress conditions, such as inflammation, malignancies, heart failure, myocardial ischemia, and many others.

aimTo explore the association between GDF-15 and IBD as serum concentrations of GDF-15 were shown to be an independent predictor of poor outcomes in multiple diseases. An additional aim was to determine possible associations between GDF-15 and multiple clinical, anthropometric and laboratory parameters in patients with IBD.

methodsThis cross-sectional study included 90 adult patients diagnosed with IBD, encompassing both Crohn's disease (CD) and ulcerative colitis (UC), and 67 healthy age- and sex-matched controls. All patients underwent an extensive workup, including colonoscopy with subsequent histopathological analysis. Disease activity was assessed by two independent gastroenterology consultants specialized in IBD, employing well-established clinical and endoscopic scoring systems. GDF-15 serum concentrations were determined following an overnight fasting, using electrochemiluminescence immunoassay.

resultsIn patients with IBD, serum GDF-15 concentrations were significantly higher in comparison to the healthy controls [800 (512-1154) pg/mL

conclusionFor the first time, we demonstrated that serum concentrations of GDF-15 are elevated in patients with IBD in comparison to healthy controls, and the results imply that GDF-15 might be involved in IBD pathophysiology. Yet, it remains elusive whether GDF-15 could serve as a prognostic indicator in these patients.

Indexed as

Growth Differentiation Factor 15Inflammatory Bowel DiseasesAdultAnemiaBiomarkersCase-Control StudiesColitis, UlcerativeColonoscopyCrohn DiseaseCross-Sectional StudiesFemaleHumansMaleMiddle AgedPatient AcuityYoung AdultBiomarkersGDF15 protein, humanGrowth Differentiation Factor 15AnemiaCrohn’s diseaseExtraintestinal manifestationsGrowth-differentiation factor-15Inflammatory bowel diseaseUlcerative colitis

Identifiers

PMID38659482
PMCPMC11036493
OpenAlexW4393677630

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.