ReviewWorld journal of gastroenterology2024
Hepatolithiasis: Epidemiology, presentation, classification and management of a complex disease.
Review in World journal of gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Comparative effectiveness and safety of robotic versus laparoscopic liver resection for benign liver diseases: a systematic review and meta-analysis.BMC gastroenterology · 2026Pooled it
- Immunometabolic crosstalk in gallstone disease: driving roles of bacterial infection, NETs and MMP activation.Molecular biology reports · 2026Review
- Development and validation of prognostic nomograms for intrahepatic cholangiocarcinoma with concomitant hepatolithiasis after radical resection.Journal of gastrointestinal oncology · 2026Article
- Intrahepatic lithiasis in Western populations: an underrecognized diagnosis and its mimickers.Abdominal radiology (New York) · 2026Review
- Application of left lateral hepatolithiasis classification in minimally invasive hepatectomy.Updates in surgery · 2026Article
- Article
- Activation of the TGR5/cAMP/PKA/CREB axis in cholangiocytes mediates epithelial-mesenchymal transition and fibrosis in hepatolithiasis.Biology direct · 2026Article
- Article
- Flexible Percutaneous Laser Lithotripsy for Intrahepatic Stones: A Multicenter Study in Western Patients.Cardiovascular and interventional radiology · 2026Article
- Article
- Laparoscopic surgery for complex hepatolithiasis: A step forward in minimally invasive hepato-pancreato-biliary surgery.World journal of hepatology · 2026Article
- Article
- Beyond chronological age: a decision tree model integrating nutritional and renal function indicators for risk prediction in pre-frail older adults with hepatolithiasis.Frontiers in medicine · 2026Article
- Laparoscopic left-sided hepatectomy guided by dilated bile ducts as anatomical landmarks for hepatolithiasis: a single-center preliminary study.Translational gastroenterology and hepatology · 2026Article
- LaparoscopicWorld journal of hepatology · 2025Article
- Article
- Electrohydraulic Lithotripsy for Hepatolithiasis With Novel VedVision Cholangioscope and New Biodegradable Stent (UNITY-B) for Intrahepatic Biliary Stricture: A Case Report With Video.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Effectiveness of enhanced recovery after surgery in elderly hepatolithiasis patients after partial hepatectomy.Pakistan journal of medical sciences · 2025Article
- Outcome of Metastatic Biliary Tract Cancer HarbouringJournal of clinical medicine · 2025Article
- Primary intrahepatic lithiasis in western countries: role of ultrasound and comparison with MRI with MRCP.European journal of gastroenterology & hepatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts, above the hilar confluence of the hepatic ducts. The disease is more prevalent in Asia, mainly owing to socioeconomic and dietary factors, as well as the prevalence of biliary parasites. In the last century, owing to migration, its global incidence has increased. The main pathophysiological mechanisms involve cholangitis, bile infection and biliary strictures, creating a self-sustaining cycle that perpetuates the disease, frequently characterised by recurrent episodes of bacterial infection referred to as syndrome of "recurrent pyogenic cholangitis". Furthermore, long-standing hepatolithiasis is a known risk factor for development of intrahepatic cholangiocarcinoma. Various classifications have aimed at providing useful insight of clinically relevant aspects and guidance for treatment. The management of symptomatic patients and those with complications can be complex, and relies upon a multidisciplinary team of hepatologists, endoscopists, interventional radiologists and hepatobiliary surgeons, with the main goal being to offer relief from the clinical presentations and prevent the development of more serious complications. This comprehensive review provides insight on various aspects of hepatolithiasis, with a focus on epidemiology, new evidence on pathophysiology, most important clinical aspects, different classification systems and contemporary management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.