Evidence map›Paper›PMID 38659416›Full record

ReviewCancer medicine2024

Association of leptin receptor polymorphisms with susceptibility of non-small cell lung cancer: Evidence from 2249 subjects.

Weifeng Tang, Jian Wang, Ting Dai, Hao Qiu, Chao Liu, Shuchen Chen, Zhendong Hu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Weifeng TangDepartments of Esophageal Surgery and Thoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu Province, China.
Jian WangDepartment of Cardiothoracic Surgery, Affiliated Yixing People's Hospital of Jiangsu University, Yixing, Jiangsu Province, China.
Ting DaiDepartment of Pharmacy, Affiliated Yixing People's Hospital of Jiangsu University, Yixing, Jiangsu Province, China.
Hao QiuDepartment of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu Province, China.
Chao LiuDepartment of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China.ORCID 0000-0003-2150-7102
Shuchen ChenDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.ORCID 0000-0002-3316-9908
Zhendong HuDepartments of Esophageal Surgery and Thoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu Province, China.
Jiangsu University · CNNanjing Drum Tower Hospital · CNFujian Medical University · CN

Funding

Initial Research Project for Talents of Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School RC2021-009Scientific Research Project of Wuxi Health Commission M202153
6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) is increasing dramatically. It is believed that energy metabolism-related genes could play an important role in etiology of NSCLC. In this study, we sought to assess the correlation between three LEPR single nucleotide polymorphisms (rs1137101, rs1137100 and rs6588147) with NSCLS susceptibility. In total, 1193 NSCLC cases and 1056 controls were included. SNPscan™ genotyping method was used to analyze the genotypes of LEPR polymorphisms. Compared to rs6588147 GG in LEPR gene, this study identified a protective role of LEPR rs6588147 GA and GA/AA for the occurrence of NSCLC (GA vs. GG [p = 0.021] and GA/AA vs. GG [p = 0.030]). As well, we found that a protective role of LEPR rs6588147 for the occurrence of non-SCC subgroup (p < 0.05). By logistic regression analysis, we found that the rs6588147 A allele related genotypes might play a protective role for the occurrence of NSCLC in drinking, BMI ≥24 kg/m

Indexed as

Carcinoma, Non-Small-Cell LungGenetic Predisposition to DiseaseLung NeoplasmsPolymorphism, Single NucleotideReceptors, LeptinAgedAllelesCase-Control StudiesFemaleGenetic Association StudiesGenotypeHumansMaleMiddle AgedLEPR protein, humanReceptors, LeptinLEPRnon‐small cell lung cancerobesityoverweightpolymorphism

Identifiers

PMID38659416
PMCPMC11043686
OpenAlexW4395466604

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.