ReviewThe European journal of neuroscience2024
Rethinking the external globus pallidus and information flow in cortico-basal ganglia-thalamic circuits.
Review in The European journal of neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 14 citations in OpenAlex.
- Dopamine dynamics as a regulatory mechanism for shifting between defensive and reward-seeking behaviors.Communications biology · 2026Article
- External Globus Pallidus Arkypallidal Circuit Dynamics Gate Risk-Taking Behavior.bioRxiv : the preprint server for biology · 2026Article
- How the dynamic interplay of cortico-basal ganglia-thalamic pathways shapes the time course of deliberation and commitment.PLoS computational biology · 2026Article
- Learning reweights the decision dynamics of cortico-basal ganglia-thalamic pathways from deliberation to commitment.bioRxiv : the preprint server for biology · 2026Article
- Motor signs in late life depression relate to altered subcortical synaptic density and gray matter volume: anNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The role of coupling among brain regions between the default mode network and the "Mesocircuit" Model in arousal in disorders of consciousness.Frontiers in neurology · 2026Article
- Motivation meets sleep: tuning arousal via nucleus accumbens and Basal Ganglia circuits.Npj biological timing and sleep · 2025Review
- Excitatory drive to the globus pallidus external segment facilitates action initiation in non-human primates.Current biology : CB · 2025Article
- Alcohol effects on associative and sensorimotor cortico-thalamo-basal ganglia circuits alter decision making and alcohol intake.Alcohol (Fayetteville, N.Y.) · 2025Review
- Matrix-biased excitatory and inhibitory inputs to the striatum involving external segment of the globus pallidus.Frontiers in cellular neuroscience · 2025Article
- CBGTPy: An extensible cortico-basal ganglia-thalamic framework for modeling biological decision making.PloS one · 2025Article
- Arkypallidal neurons in the external globus pallidus can mediate inhibitory control by altering competition in the striatum.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- CBGTPy: An extensible cortico-basal ganglia-thalamic framework for modeling biological decision making.bioRxiv : the preprint server for biology · 2024Article
- Cortical, subcortical, and cerebellar atrophy and cognition deficits in Metropolitan Mexico City teens and young adults exposed to fine particulate matter (PMFrontiers in neurologyArticle
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
For decades, the external globus pallidus (GPe) has been viewed as a passive way-station in the indirect pathway of the cortico-basal ganglia-thalamic (CBGT) circuit, sandwiched between striatal inputs and basal ganglia outputs. According to this model, one-way descending striatal signals in the indirect pathway amplify the suppression of downstream thalamic nuclei by inhibiting GPe activity. Here, we revisit this assumption, in light of new and emerging work on the cellular complexity, connectivity and functional role of the GPe in behaviour. We show how, according to this new circuit-level logic, the GPe is ideally positioned for relaying ascending and descending control signals within the basal ganglia. Focusing on the problem of inhibitory control, we illustrate how this bidirectional flow of information allows for the integration of reactive and proactive control mechanisms during action selection. Taken together, this new evidence points to the GPe as being a central hub in the CBGT circuit, participating in bidirectional information flow and linking multifaceted control signals to regulate behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.