Evidence map›Paper›PMID 38659049›Full record

ReviewJournal of eating disorders2024

Psilocybin therapy and anorexia nervosa: a narrative review of safety considerations for researchers and clinicians.

Amanda E Downey, Anita V Chaphekar, Joshua Woolley, Marissa Raymond-Flesch

Open access · goldAbstract readReview
In one paragraph

Review in Journal of eating disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Amanda E DowneyDepartment of Pediatrics, University of California, San Francisco, CA, USA. amanda.downey@ucsf.edu.
Anita V ChaphekarDepartment of Pediatrics, University of California, San Francisco, CA, USA.
Joshua WoolleyDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
Marissa Raymond-FleschDepartment of Pediatrics, University of California, San Francisco, CA, USA.
University of California, San Francisco · USLee University · USSan Francisco VA Medical Center · US

Funding

CLINICAL, PHARMACOLOGY, DRUG ACTION &PHARMACOKINETICST32GM007546 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Radojka Savic · 1985 to 2026
$8.9M
CSR&D Research Career Development Transition Award ApplicationIK4CX002090 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI WOOLLEY, JOSH · 2020 to 2024
–
CSRD VA IK4 CX002090NIGMS NIH HHS T32 GM007546
6 · The paper itself

Abstract

backgroundClinical trials using psilocybin therapy to treat anorexia nervosa (AN) are currently underway. The safety and tolerability of psilocybin is of utmost importance in individuals with AN who may present unique medical vulnerabilities. The purpose of this review is to describe how the common physiologic adverse effects of psilocybin may impact medical complications experienced by individuals with AN in clinical trials of psilocybin therapy. MAIN BODY: The physiologic underpinnings of common adverse effects following psilocybin administration are described, including tachycardia, hypertension, electrocardiogram changes, nausea, headache, and lightheadedness. These anticipated physiologic changes are described in relation to the common medical correlates seen in individuals with AN. Risk mitigation strategies for each adverse effect are proposed.

conclusionEarly evidence suggests that psilocybin therapy is well-tolerated in individuals with AN. Understanding the unique medical complications of AN, and how they may be impacted by common physiologic adverse effects of psilocybin administration, leads to tailored risk mitigation strategies to enhance safety and tolerability of this novel intervention.

Indexed as

Adverse effectsAnorexia nervosaClinical trialPsilocybin

Identifiers

PMID38659049
PMCPMC11040882
OpenAlexW4395110324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.