ArticleCardiovascular diabetology2024
Systolic blood pressure status modifies the associations between the triglyceride-glucose index and incident cardiovascular disease: a national cohort study in China.
Article in Cardiovascular diabetology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 13 citations in OpenAlex.
- Interplay between triglyceride-glucose index and cardiovascular events in hypertensive patients with controlled blood pressure (SBP<140 mmHg): insights from the SPRINT trial.Frontiers in endocrinology · 2025Trial
- Association between Serum Metal Levels and Blood Pressure in Aluminium Smelting Workers: Mediating Role of Gamma-Glutamyltransferase.Biological trace element research · 2026Article
- The Effect Modification of Systolic Blood Pressure on the Association of Frailty and Cardiovascular Disease in Community-Dwelling Adults.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Comparative prognostic value of TyG index and TyG-BMI for 90-day all-cause mortality in critically ill older adults with ASCVD: a machine learning analysis of the MIMIC-IV database.Cardiovascular diabetology · 2026Article
- Joint associations of anthropometric indices and C-reactive protein-triglyceride-glucose index with incident hypertension: a stratified analysis by blood pressure level from the CHARLS, 2011-2020.Cardiovascular diabetology · 2026Article
- Association between the combined c-reactive protein-triglyceride glucose index and hypertension with long-term stroke among cardiovascular-kidney-metabolic syndrome stages 0-3 population: a nationwide prospective cohort study.Cardiovascular diabetology · 2026Article
- Body Roundness Index Mediates the Association Between Triglyceride-Glucose Index and Hypertension: A Cross-Sectional Study.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Diabetes modifies the association between the triglyceride-glucose index and subclinical myocardial injury: A prospective cohort study.Cardiovascular diabetology · 2025Article
- Association Between Triglyceride-Glucose Index, Blood Pressure Status, and Coronary Heart Disease Risk Among Chinese Adults With Disabilities: 10-Year Disability Health Survey Cohort Study.JMIR public health and surveillance · 2025Article
- Association between the triglyceride glucose-body roundness index and the incidence of cardiovascular disease among Chinese middle and old-aged adults: a nationwide prospective cohort study.Acta diabetologica · 2025Article
- Effect of changes in the triglyceride-glucose index on atherogenic lipid profiles in coronary artery disease patients receiving lipid-lowering therapy: a prospective cohort study.Cardiovascular diabetology · 2025Article
- Blood Pressure Levels and Triglyceride-Glucose Index: A Cross-Sectional Study from a Nationwide Screening in Mongolia.Journal of clinical medicine · 2025Article
- Triglyceride-glucose index: carotid intima-media thickness and cardiovascular risk in a European population.Cardiovascular diabetology · 2025Article
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4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe triglyceride-glucose (TyG) index and blood pressure (BP) are correlated and serve as risk factors for cardiovascular disease (CVD). The potential impact of BP status on the association between the TyG index and CVD risk remains uncertain. This study aims to investigate the relationships between the TyG index and incident CVD in Chinese middle-aged and elderly adults, considering variations in BP status among participants.
methods6558 participants (mean age: 58.3 (± 8.7) years; 46.0% were men) without prevalent CVD were recruited from the China Health and Retirement Longitudinal Study. Participants were divided into three groups according to their systolic blood pressure (SBP) levels (< 120mmHg, 120 ∼ 129mmHg, ≥ 130mmHg). The TyG index was computed as ln[triglyceride (mg/dl) * fasting blood glucose (mg/dl)/2]. The primary outcome was CVD (heart disease and stroke), and the secondary outcomes were individual CVD components. Cox regression models and restricted cubic splines were performed to investigate the associations between continuous and categorical TyG with CVD.
results1599 cases of CVD were captured during 58,333 person-years of follow-up. Per 1-SD higher TyG index was associated with a 19% (HR: 1.19; 95% CI: 1.12, 1.27) higher risk for incident CVD, and the participants with the highest quartile of TyG index had a 54% (HR: 1.54; 95% CI: 1.29, 1.84) higher risk of CVD compared to those in the lowest quartile. SBP significantly modifies the association between the TyG index and CVD, with higher HRs for CVD observed in those with optimal and normal SBP. SBP partially mediated the associations between the TyG index with CVD. The results were generally consistent among participants with varying pulse pressure statuses rather than diastolic BP statuses.
conclusionsThe associations between the TyG index and CVD were modified by BP status, with greater HRs for CVD observed among those who had SBP < 130mmHg. SBP can partially mediate the association between the TyG index with CVD, highlighting the importance of early screening for the TyG index to identify at risk of hypertension and CVD.
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