Evidence map›Paper›PMID 38658858›Full record

ArticleBMC cancer2024

Gut microbiota composition and metabolic characteristics in patients with Craniopharyngioma.

Chunhui Liu, Fangzheng Liu, Ding Nie, Youchao Xiao, Wentao Wu, Yanfei Jia, Lu Jin, Ning Qiao, Kefan Cai, Siming Ru and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Chunhui Liu *Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100071, China.
Fangzheng Liu *Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100071, China.
Ding NieBeijing Neurosurgical Institute, Capital Medical University, Beijing, 100071, China.
Youchao XiaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100071, China.
Wentao WuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100071, China.
Yanfei JiaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100071, China.
Lu JinDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100071, China.
Ning QiaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100071, China.
Kefan CaiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100071, China.
Siming RuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100071, China.
Xin LiuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100071, China.
Yifan SongDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100071, China.
Jintian XuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100071, China.
Lei CaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100071, China.
Songbai GuiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100071, China. guisongbai@ccmu.edu.cn.
Beijing Tian Tan Hospital · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmerging evidence suggests that the gut microbiota is associated with various intracranial neoplastic diseases. It has been observed that alterations in the gut microbiota are present in gliomas, meningiomas, and pituitary neuroendocrine tumors (Pit-NETs). However, the correlation between gut microbiota and craniopharyngioma (CP), a rare embryonic malformation tumor in the sellar region, has not been previously mentioned. Consequently, this study aimed to investigate the gut microbiota composition and metabolic patterns in CP patients, with the goal of identifying potential therapeutic approaches.

methodsWe enrolled 15 medication-free and non-operated patients with CP and 15 healthy controls (HCs), conducting sequential metagenomic and metabolomic analyses on fecal samples to investigate changes in the gut microbiota of CP patients.

resultsThe composition of gut microbiota in patients with CP compared to HCs show significant discrepancies at both the genus and species levels. The CP group exhibits greater species diversity. And the metabolic patterns between the two groups vary markedly.

conclusionsThe gut microbiota composition and metabolic patterns in patients with CP differ significantly from the healthy population, presenting potential new therapeutic opportunities.

Indexed as

CraniopharyngiomaFecesGastrointestinal MicrobiomePituitary NeoplasmsAdolescentAdultCase-Control StudiesFemaleHumansMaleMetabolomeMetabolomicsMetagenomicsMiddle AgedYoung AdultCraniopharyngiomaGut-brain axisGut microbiotaHypothalamic-pituitary-adrenal axis

Identifiers

PMID38658858
PMCPMC11044453
OpenAlexW4395462465

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.