ArticleNature immunology2024
JAK-STAT signaling maintains homeostasis in T cells and macrophages.
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Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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66citing papers in PubMed
22.3field-weighted citation impact, top 1% of its field
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66 citing papers in PubMed, 79 citations in OpenAlex.
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- Distinctive T Cell Patterns Defining Lymphocytic Alopecia and Alternate Autoimmune and Stem Cell Pathways, Linked to Pleiotropic Functions of Regulatory T Cells Within iSALT.The American Journal of dermatopathology · 2026Review
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- Macrophage USP9X attenuates colitis by restricting oncostatin M production via K27-linked deubiquitination of STAT1.Cellular & molecular immunology · 2026Article
- Lipoic Acid-Intervened Decellularized Stem Cell Spheroid-Based Injectable Granular Gel for Diabetic Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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- Combining Small-Molecular Compounds With CAR T-Cell Therapy: Novel Strategies for Enhanced Cancer Immunotherapy.Cancer innovation · 2026Review
- IFITM3-mediated neuroinflammation in epilepsy regulated by the let-7g-5p/STAT2 axis.Scientific reports · 2026Article
- Dual PD-1/IL-2Rα targeting restores CD8Cell reports. Medicine · 2026Article
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- Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine-Dependent Pro-Inflammatory Immune Microenvironment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tubule-Derived IFN-α Promotes GSDMD-Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dissecting glioblastoma risk signatures in the tumor immune microenvironment based on multi-dimensional transcriptomics.GigaScience · 2026Article
- Eutopic Endometrium Immune Changes Involved in Development and Progression of Endometriosis: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Immune checkpoint blockade in cancer: current insights and future horizons.Discover oncology · 2026Review
- Tofacitinib combined with fire needle therapy for refractory cutaneous Rosai-Dorfman disease: a first case report and literature review.Frontiers in medicine · 2026Article
- Shift work disrupts Immune regulation of the transcriptome in hospital nurses.Frontiers in public health · 2026Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
38 authors at 7 institutions in 1 country.
Nikolaus Fortelny *CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.ORCID http://orcid.org/0000-0003-4025-9968
Matthias Farlik *CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. matthias.farlik@meduniwien.ac.at.ORCID http://orcid.org/0000-0003-0698-2992
Victoria FifeCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.ORCID http://orcid.org/0000-0003-0052-5731
Anna-Dorothea GorkiResearch Division of Infection Biology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-2521-0333
Caroline LassnigAnimal Breeding and Genetics and VetBiomodels, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria.
Barbara MaurerPharmacology and Toxicology, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria.
Katrin MeisslAnimal Breeding and Genetics and VetBiomodels, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria.
Marlies DolezalPlatform for Bioinformatics and Biostatistics, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria.
Laura BoccuniMax Perutz Labs, University of Vienna, Vienna, Austria.
Aarathy Ravi Sundar Jose GeethaMax Perutz Labs, University of Vienna, Vienna, Austria.
Mojoyinola Joanna AkaghaAnimal Breeding and Genetics and VetBiomodels, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria.ORCID http://orcid.org/0000-0002-9940-232X
Anzhelika KarjalainenAnimal Breeding and Genetics and VetBiomodels, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria.
Stephen ShoebridgeAnimal Breeding and Genetics and VetBiomodels, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria.ORCID http://orcid.org/0000-0002-3555-2855
Asma FarhatResearch Division of Infection Biology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Ulrike MannDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Rohit JainDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-4905-462X
Shweta TikooDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0001-5850-8075
Nina ZilaDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0003-1193-1014
Wolfgang Esser-SkalaCenter for Tumor Biology and Immunology, Department of Biosciences and Medical Biology, Paris-Lodron University Salzburg, Salzburg, Austria.
Thomas KrausgruberCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.ORCID http://orcid.org/0000-0002-1374-0329
Katarzyna SitnikAnimal Breeding and Genetics and VetBiomodels, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria.ORCID http://orcid.org/0000-0002-6965-0322
Thomas PenzCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Anastasiya HladikResearch Division of Infection Biology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Tobias SuskeAnimal Breeding and Genetics and VetBiomodels, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria.
Sophie ZahalkaResearch Division of Infection Biology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Martin SenekowitschCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Daniele BarrecaCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Florian HalbritterCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.ORCID http://orcid.org/0000-0003-2452-4784
Sabine Macho-MaschlerAnimal Breeding and Genetics and VetBiomodels, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria.
Wolfgang WeningerDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Heidi A NeubauerAnimal Breeding and Genetics and VetBiomodels, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria.ORCID http://orcid.org/0000-0001-7372-7786
Richard MorigglAnimal Breeding and Genetics and VetBiomodels, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria.ORCID http://orcid.org/0000-0003-0918-9463
Sylvia KnappResearch Division of Infection Biology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0001-9016-5244
Veronika SexlPharmacology and Toxicology, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria.
Birgit StroblAnimal Breeding and Genetics and VetBiomodels, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria.ORCID http://orcid.org/0000-0001-5716-3212
Thomas DeckerMax Perutz Labs, University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0001-9683-0620
Mathias MüllerAnimal Breeding and Genetics and VetBiomodels, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine, Vienna, Austria.ORCID http://orcid.org/0000-0002-7879-3552
Christoph BockCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. cbock@cemm.oeaw.ac.at.ORCID http://orcid.org/0000-0001-6091-3088
University of Veterinary Medicine Vienna · ATMedical University of Vienna · ATAustrian Academy of Sciences · ATUniversity of Vienna · ATAustrian Research Institute for Artificial Intelligence · ATCeMM Research Center for Molecular Medicine · ATUniversity of Salzburg · AT
Funding
Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) F6101Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) F6102Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) F6103Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) F6104Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) F6105Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) F6106Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) F6107Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) F6108Austrian Science Fund FWF W 1261EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 101001971European Molecular Biology Organization (EMBO) ALTF 241-2017
Abstract
Immune cells need to sustain a state of constant alertness over a lifetime. Yet, little is known about the regulatory processes that control the fluent and fragile balance that is called homeostasis. Here we demonstrate that JAK-STAT signaling, beyond its role in immune responses, is a major regulator of immune cell homeostasis. We investigated JAK-STAT-mediated transcription and chromatin accessibility across 12 mouse models, including knockouts of all STAT transcription factors and of the TYK2 kinase. Baseline JAK-STAT signaling was detected in CD8
Indexed as
HomeostasisJanus KinasesMacrophagesMice, KnockoutSignal TransductionSTAT Transcription FactorsAnimalsCD8-Positive T-LymphocytesGene Expression RegulationInterferon-Stimulated Gene Factor 3, gamma SubunitMiceMice, Inbred C57BLSTAT1 Transcription FactorTYK2 KinaseInterferon-Stimulated Gene Factor 3, gamma SubunitJanus KinasesStat1 protein, mouseSTAT1 Transcription FactorSTAT Transcription FactorsTYK2 Kinase
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