Evidence map›Paper›PMID 38658786›Full record

ArticleNature microbiology2024

Age and sex influence antibody profiles associated with tuberculosis progression.

Leela R L Davies, Chuangqi Wang, Pia Steigler, Kathryn A Bowman, Stephanie Fischinger, Mark Hatherill, Michelle Fisher, Stanley Kimbung Mbandi, Miguel Rodo, Tom H M Ottenhoff and 11 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Body Mass Index and Incident Tuberculosis in Close Tuberculosis Contacts.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Observational
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Antigen specificity shapes antibody functions in tuberculosis.bioRxiv : the preprint server for biology · 2024
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 12 institutions in 6 countries.

Leela R L Davies *Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-4780-0606
Chuangqi Wang *Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-4779-2231
Pia SteiglerSouth African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Kathryn A BowmanRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-4222-5286
Stephanie FischingerRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
Mark HatherillSouth African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0003-3491-1809
Michelle FisherSouth African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Stanley Kimbung MbandiSouth African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-6121-9039
Miguel RodoSouth African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Tom H M OttenhoffDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-3706-3403
Hazel M DockrellVaccines and Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul, The Gambia.ORCID http://orcid.org/0000-0003-1869-9107
Jayne S SutherlandVaccines and Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul, The Gambia.ORCID http://orcid.org/0000-0002-7083-4997
Harriet Mayanja-KizzaDepartment of Medicine and Department of Microbiology, Makerere University, Kampala, Uganda.
W Henry BoomTuberculosis Research Unit, Case Western Reserve University, Cleveland, OH, USA.
Gerhard WalzlDepartment of Science and Technology National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID http://orcid.org/0000-0003-2487-125X
Stefan H E KaufmannMax Planck Institute for Infection Biology, Berlin, Germany.ORCID http://orcid.org/0000-0001-9866-8268
Elisa NemesSouth African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0003-1662-4961
Thomas J ScribaSouth African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-0641-1359
Douglas LauffenburgerBiological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-0050-989X
Galit AlterRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA. galit.alter@modernatx.com.ORCID http://orcid.org/0000-0002-7680-9215
Sarah M FortuneDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA. sfortune@hsph.harvard.edu.ORCID http://orcid.org/0000-0001-7565-9975
University of Cape Town · ZABrigham and Women's Hospital · USMRC Unit the Gambia · GMRagon Institute of MGH, MIT and Harvard · USCase Western Reserve University · USHarvard University · USInstitute for Advanced Study · USLeiden University Medical Center · NLMakerere University · UGMassachusetts Institute of Technology · USSouth African Medical Research Council · ZAUniversity of Colorado Anschutz Medical Campus · US

Funding

IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB)75N93019C00071 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI FORTUNE, SARAH · 2019 to 2025
$57.3M
Multidisciplinary HIV Training ProgramT32AI007387 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Daniel R. Kuritzkes · 1990 to 2026
$8.8M
Characterizing the humoral response to lipoarabinomannan in tuberculosis progressionK08AI167766 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI DAVIES, LEELA · 2022 to 2022
$195k
Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation) GC12 grant 37885Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation) GC6-74 grant 37772Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation) OPP1023483Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation) OPP1065330NIAID NIH HHS 75N93019C00071NIAID NIH HHS K08 AI167766NIAID NIH HHS T32 AI007387U.S. Department of Health & Human Services | National Institutes of Health (NIH) K08AI167766
6 · The paper itself

Abstract

Antibody features vary with tuberculosis (TB) disease state. Whether clinical variables, such as age or sex, influence associations between Mycobacterium tuberculosis-specific antibody responses and disease state is not well explored. Here we profiled Mycobacterium tuberculosis-specific antibody responses in 140 TB-exposed South African individuals from the Adolescent Cohort Study. We identified distinct response features in individuals progressing to active TB from non-progressing, matched controls. A multivariate antibody score differentially associated with progression (SeroScore) identified progressors up to 2 years before TB diagnosis, earlier than that achieved with the RISK6 transcriptional signature of progression. We validated these antibody response features in the Grand Challenges 6-74 cohort. Both the SeroScore and RISK6 correlated better with risk of TB progression in adolescents compared with adults, and in males compared with females. This suggests that age and sex are important, underappreciated modifiers of antibody responses associated with TB progression.

Indexed as

Antibodies, BacterialDisease ProgressionMycobacterium tuberculosisTuberculosisAdolescentAdultAge FactorsAntibody FormationCohort StudiesFemaleHumansMaleSex FactorsSouth AfricaYoung AdultAntibodies, Bacterial

Identifiers

PMID38658786
PMCPMC11153143
OpenAlexW4395112972

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.