Evidence map›Paper›PMID 38658768›Full record

ArticleClinical and translational medicine2024

Inhibition of autophagy antagonizes breast cancer brain metastogenesis and augments the anticancer activity of lapatinib.

Steffan T Nawrocki, Claudia M Espitia, Maria Janina Carrera Espinoza, Trace M Jones, Madison E Gamble, Sruthi Sureshkumar, Mengyang Chang, Wei Wang, Jennifer S Carew

Abstract readLetter
In one paragraph

Article in Clinical and translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Steffan T NawrockiDepartment of Medicine, Division of Hematology and Oncology, University of Arizona Cancer Center, Tucson, Arizona, USA.
Claudia M EspitiaDepartment of Medicine, Division of Hematology and Oncology, University of Arizona Cancer Center, Tucson, Arizona, USA.
Maria Janina Carrera EspinozaDepartment of Medicine, Division of Hematology and Oncology, University of Arizona Cancer Center, Tucson, Arizona, USA.
Trace M JonesDepartment of Medicine, Division of Hematology and Oncology, University of Arizona Cancer Center, Tucson, Arizona, USA.
Madison E GambleDepartment of Medicine, Division of Hematology and Oncology, University of Arizona Cancer Center, Tucson, Arizona, USA.
Sruthi SureshkumarDepartment of Medicine, Division of Hematology and Oncology, University of Arizona Cancer Center, Tucson, Arizona, USA.
Mengyang ChangDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA.
Wei WangDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA.
Jennifer S CarewDepartment of Medicine, Division of Hematology and Oncology, University of Arizona Cancer Center, Tucson, Arizona, USA.ORCID 0000-0002-8578-8292

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
Integrative Cancer Scholars Training GrantT32CA009213 · NCI · UNIVERSITY OF ARIZONA · PI CAREW, JENNIFER S, CURIEL-LEWANDROWSKI, CLARA · 1985 to 2024
$8.6M
Targeting Lysosomal Vulnerabilities in Renal PathogenesisR01CA268383 · NCI · UNIVERSITY OF ARIZONA · PI Jennifer S Carew, Steffan T Nawrocki · 2022 to 2026
$2.4M
Endoplasmic reticulum stress and oncoviral therapyR01CA190789 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI NAWROCKI, STEFFAN T · 2015 to 2020
$1.6M
Disrupting Brain Metastogenesis in Breast CancerR21CA184649 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI NAWROCKI, STEFFAN T · 2014 to 2015
$325k
NCI NIH HHS P30 CA023074NCI NIH HHS R01 CA190789NCI NIH HHS R01 CA268383NCI NIH HHS R21 CA184649NCI NIH HHS T32 CA009213NIH HHS P30CA023074NIH HHS R01CA190789NIH HHS R01CA268383NIH HHS R21CA184649NIH HHS T32CA009213
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic AgentsAutophagyBreast NeoplasmsLapatinibBrain NeoplasmsFemaleHumansAntineoplastic AgentsLapatinib

Identifiers

PMID38658768
PMCPMC11043092

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.