ArticleNature2024
Periportal macrophages protect against commensal-driven liver inflammation.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
36.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed, 95 citations in OpenAlex.
- Unraveling the Multifaceted Roles of Tissue-Resident Macrophages: Focus on Bone Homeostasis and Regeneration.Stem cell reviews and reports · 2026Review
- A human single-cell atlas identifies OLR1Nature genetics · 2026Article
- Size-dependent plastic exposure disrupts macrophage function and tissue-specific metabolism.Nature metabolism · 2026Article
- Integrated single-cell multiomics reveals neutrophil-driven immune-metabolic reprogramming of Kupffer cells via thrombospondin-1/CD36 after surgical stress.JCI insight · 2026Article
- A transferable gut microbiota-bile acid pathway programs nanomedicine pharmacokinetics and therapeutic response.Nature materials · 2026Article
- Perioperative gut microbial ecology: a new frontier for improving the prognosis of hepatocellular carcinoma surgery.Precision clinical medicine · 2026Review
- Molecular mechanisms and pathogenesis of MASH.Nature · 2026Review
- Targeting the immune-metabolic axis reverses orthodontics-induced systemic pathology.Signal transduction and targeted therapy · 2026Article
- Gut mucosal barrier: the frontline of bidirectional regulation of the gut-X axis.Medical review (2021) · 2026Review
- LYNX: a deep generative model for linking spatial dynamics and cell interactions in multimodal spatial data.bioRxiv : the preprint server for biology · 2026Article
- Macrophage signaling associates with fibrogenic program activation in periductal fibroblasts in pediatric primary sclerosing cholangitis.JCI insight · 2026Article
- The hepatic portal area in homeostasis and disease.Clinical and molecular hepatology · 2026Article
- Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers.Nature reviews. Immunology · 2026Review
- Research Progress on Downstream Mechanisms of Glucose Metabolic Reprogramming and Its Role in the Occurrence and Progression of Type 2 Diabetes Mellitus.Biomedicines · 2026Review
- Liver endothelial zonation orchestrates hepatic steatosis onset through retinoic acid-regulated FGF1.Science advances · 2026Article
- Liver sinusoidal endothelial cell fenestrations in metabolic liver disease: from molecular mechanisms to therapeutic perspectives.Cell communication and signaling : CCS · 2026Review
- Kupffer cells: Orchestrators of liver physiology.Liver research (Beijing, China) · 2026Review
- Periportal hepatocytes secret SAA1 to recruit MoKCs and interactions through CADM1 signaling to promote MASLD.Hepatology international · 2026Article
- Integrated multi-omics identifies distinct macrophage alterations during progression of metabolic dysfunction-associated steatohepatitis.Nature genetics · 2026Article
- Pharmabiotics, Phocaeicola dorei, ameliorates cholestatic liver fibrosis by alleviating macrophage efferocytosis of neutrophils.Nature communications · 2026Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 5 institutions in 2 countries.
Yu MiyamotoDepartment of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan.ORCID 0000-0002-2715-6465
Junichi KikutaDepartment of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan.ORCID 0000-0002-1549-5961
Takahiro MatsuiDepartment of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan.
Tetsuo HasegawaDepartment of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan.
Kentaro FujiiDepartment of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan.
Daisuke OkuzakiWPI-Immunology Frontier Research Center, Osaka University, Osaka, Japan.ORCID 0000-0002-4552-783X
Yu-Chen LiuWPI-Immunology Frontier Research Center, Osaka University, Osaka, Japan.ORCID 0000-0002-2750-0182
Takuya YoshiokaLaboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.ORCID 0009-0000-7217-5852
Shigeto SenoDepartment of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University, Osaka, Japan.ORCID 0000-0003-3861-6444
Daisuke MotookaWPI-Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Yutaka UchidaDepartment of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan.
Erika YamashitaDepartment of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan.ORCID 0000-0002-3973-9529
Shogo KobayashiDepartment of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Hidetoshi EguchiDepartment of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Eiichi MoriiDepartment of Pathology, Graduate School of Medicine, Osaka University, Osaka, Japan.ORCID 0000-0001-8490-3650
Karl TryggvasonCardiovascular and Metabolic Disorders Program, Duke-NUS, Duke-NUS Medical School, Singapore, Singapore.
Takashi ShichitaLaboratory for Neuroinflammation and Repair, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.ORCID 0000-0003-1110-1926
Hisako KayamaWPI-Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Koji AtarashiDepartment of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan.ORCID 0000-0001-5422-0736
Jun KunisawaLaboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.ORCID 0000-0003-4901-1125
Kenya HondaDepartment of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan.ORCID 0000-0001-8937-9835
Kiyoshi TakedaWPI-Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Masaru IshiiDepartment of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan. mishii@icb.med.osaka-u.ac.jp.ORCID 0000-0002-4215-007X
The University of Osaka · JPNational Institute of Biomedical Innovation, Health and Nutrition · JPKeio University · JPDuke-NUS Medical School · SGTokyo Medical and Dental University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
The liver is the main gateway from the gut, and the unidirectional sinusoidal flow from portal to central veins constitutes heterogenous zones, including the periportal vein (PV) and the pericentral vein zones
Indexed as
Cholangitis, SclerosingGastrointestinal MicrobiomeInflammationLiverMacrophagesNon-alcoholic Fatty Liver DiseaseSymbiosisAnimalsBacteroidetesFemaleGene Expression ProfilingHumansInterleukin-10MaleMiceMice, Inbred C57BLInterleukin-10isoallolithocholic acidMarco protein, mousePhenanthrenesReceptors, Immunologic
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.